Optimum Nutrition Micronized Creatine Monohydrate Powder, Unflavored, 120 Servings, 600 Grams (Packaging May Vary)

Clinical trials typically use 3-5 g daily (creatine monohydrate). Optimum Nutrition Micronized Creatine Monohydrate Powder delivers 5g per serving, which we classify as Therapeutic relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Micronized powder vs alternatives), dose adequacy, and third-party testing.

Yes — Informed Choice + Creapure. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Creatine monohydrate has no significant drug interactions in healthy adults. However, individuals taking nephrotoxic medications or those with pre-existing kidney conditions should consult a physician. NSAIDs combined with creatine may theoretically increase renal stress, though no clinical evidence supports this concern at standard 3-5g doses.

The American Academy of Pediatrics considers creatine supplementation acceptable for athletes 18 and older. For younger athletes, the ISSN notes that 3g/day appears safe in adolescents engaged in supervised training, though more research is needed. Optimum Nutrition recommends this product for adults.

No. Over 30 years of research shows creatine monohydrate at 3-5g daily does not impair kidney function in healthy individuals. Creatinine levels may rise slightly (a natural byproduct of creatine metabolism), but this does not indicate kidney damage. Individuals with pre-existing kidney disease should consult a physician.

Yes. While early studies suggested caffeine might negate creatine benefits, recent research shows they can be taken together without issue. Optimum Nutrition creatine is unflavored and caffeine-free, making it easy to combine with coffee or pre-workout supplements.

Yes. The ISSN position stand confirms that daily creatine supplementation at 3-5g is safe for long-term use without cycling. Creatine does not suppress natural production — your body continues to synthesize creatine normally while supplementing.

Take one scoop (5g) daily mixed with water, juice, or a protein shake. This dose is consistent with the clinical evidence showing 3-5g daily saturates muscle creatine stores within 3-4 weeks. No loading phase is required, though 20g/day for 5-7 days achieves saturation faster.