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Acetyl-L-Carnitine (ALCAR) Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

1-3 g daily, divided into 2-3 doses

Maximum dose: 3 g/day is the typical maximum used in clinical trials

Dosage Recommendations

General recommendation: 1-3 g daily, divided into 2-3 doses

Timing: Morning and early afternoon to avoid potential sleep disruption from mild stimulatory effects

Dosage by Condition

Cognitive support
1.5-3 g daily in divided dosesModerate
Neuropathic pain
2-3 g dailyStrong
Depression (adjunct)
1-3 g dailyModerate
Anti-aging / mitochondrial support
1-2 g dailyModerate

Upper limit: 3 g/day is the typical maximum used in clinical trials

Timing & Absorption

Morning and early afternoon to avoid potential sleep disruption from mild stimulatory effects

Can be taken with or without food.

Full Acetyl-L-Carnitine (ALCAR) Guide

References

  1. Veronese N, Stubbs B, Solmi M, et al. (2018). Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosomatic Medicine. DOI PubMed
  2. Li S, Li Q, Li Y, et al. (2015). Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis. Journal of the Peripheral Nervous System. DOI PubMed
  3. Montgomery SA, Thal LJ, Amrein R. (2003). Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. International Clinical Psychopharmacology. DOI PubMed
  4. Tejani AM, Wasdell M, Spiwak R, Rowell G, et al. (2010). Carnitine for fatigue in multiple sclerosis.. The Cochrane database of systematic reviews. DOI PubMed