General Dosage
Follow individual ingredient dosages; adrenal complexes typically taken 1-2 times daily with meals
Maximum dose: Varies by ingredient — do not exceed individual ingredient maximums
Adrenal Support Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: Follow individual ingredient dosages; adrenal complexes typically taken 1-2 times daily with meals
Timing: Morning and early afternoon to align with natural cortisol rhythm; avoid evening dosing of stimulating adaptogens • Take with food for best absorption.
Dosage by Condition
Chronic stress / burnout
Ashwagandha 300mg + Rhodiola 200mg twice dailyModerate
Morning fatigue
Adaptogen complex in morning; B-complex + vitamin CModerate
Cortisol modulation
Phosphatidylserine 400mg + ashwagandha 300mg dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Chronic stress / burnout | Ashwagandha 300mg + Rhodiola 200mg twice daily | Moderate |
| Morning fatigue | Adaptogen complex in morning; B-complex + vitamin C | Moderate |
| Cortisol modulation | Phosphatidylserine 400mg + ashwagandha 300mg daily | Moderate |
Upper limit: Varies by ingredient — do not exceed individual ingredient maximums
Timing & Absorption
Morning and early afternoon to align with natural cortisol rhythm; avoid evening dosing of stimulating adaptogens
Best taken with food for optimal absorption.
References
- RCTLopresti AL, Smith SJ, Malvi H, Kodgule R (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Medicine. DOI PubMed
- RCTOlsson EM, von Schéele B, Panossian AG (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Medica. DOI PubMed
- RCTHellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D (2004). Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. DOI PubMed