General Dosage
25-50 mg synephrine daily, alone or before exercise
Maximum dose: 50 mg synephrine/day for most adults; avoid combining with high-dose caffeine or other stimulants
Bitter Orange (Synephrine) Dosage Guide
Evidence:Emerging
·
This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 25-50 mg synephrine daily, alone or before exercise
Timing: Take in the morning or before exercise; avoid evening dosing
Dosage by Condition
Thermogenesis
25-50 mg synephrine dailyEmerging
Pre-exercise fat oxidation
2-3 mg/kg synephrine 60 min before exerciseEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Thermogenesis | 25-50 mg synephrine daily | Emerging |
| Pre-exercise fat oxidation | 2-3 mg/kg synephrine 60 min before exercise | Emerging |
Upper limit: 50 mg synephrine/day for most adults; avoid combining with high-dose caffeine or other stimulants
Timing & Absorption
Take in the morning or before exercise; avoid evening dosing
Can be taken with or without food.