Safety Profile
Overall safety rating: Generally Safe
Bitter Orange (Synephrine) Side Effects & Safety
Evidence:Emerging
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Potential Side Effects
- Generally well tolerated at standard doses
- Possible headache, jitteriness when combined with caffeine
- Rare elevation in blood pressure with high doses or stimulant combinations
- Insomnia if taken late in the day
Drug & Supplement Interactions
- Caffeine — combination may increase cardiovascular effects; use moderate caffeine doses
- MAOIs — contraindicated (risk of hypertensive crisis)
- Other stimulants (ephedrine, yohimbine) — avoid stacking multiple sympathomimetics
- Blood pressure medications — may counteract their effects
Maximum Dose
Do not exceed: 50 mg synephrine/day for most adults; avoid combining with high-dose caffeine or other stimulants