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Bitter Orange (Synephrine) Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well tolerated at standard doses
  • Possible headache, jitteriness when combined with caffeine
  • Rare elevation in blood pressure with high doses or stimulant combinations
  • Insomnia if taken late in the day

Drug & Supplement Interactions

  • Caffeine — combination may increase cardiovascular effects; use moderate caffeine doses
  • MAOIs — contraindicated (risk of hypertensive crisis)
  • Other stimulants (ephedrine, yohimbine) — avoid stacking multiple sympathomimetics
  • Blood pressure medications — may counteract their effects

Maximum Dose

Do not exceed: 50 mg synephrine/day for most adults; avoid combining with high-dose caffeine or other stimulants

Full Bitter Orange (Synephrine) Guide

References

  1. (). A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. International Journal of Medical Sciences. DOI