Evidence Level
Emerging
Synephrine/bitter orange has emerged as the primary stimulant ingredient in weight loss supplements post-ephedra ban. Its beta-3 selectivity provides a thermogenic effect with a better cardiovascular safety profile than ephedra. However, clinical evidence for actual weight loss is limited — most data demonstrates metabolic rate increases and fat oxidation enhancement rather than significant body weight reduction. It is generally safe alone at standard doses but caution is warranted with stimulant combinations.