Safety Profile
Overall safety rating: Generally Safe
Boswellia Side Effects & Safety
Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Mild gastrointestinal discomfort (nausea, acid reflux) in some users
- Rare skin rash or allergic reaction
- Diarrhea at high doses
Drug & Supplement Interactions
- Anticoagulants — boswellia may have mild antiplatelet activity; monitor if combining with blood thinners
- NSAIDs — additive anti-inflammatory effects; may allow NSAID dose reduction under medical supervision
- Immunosuppressants — theoretical interaction due to immune-modulating effects
Maximum Dose
Do not exceed: Up to 1,200mg/day has been used in clinical trials without significant adverse effects
References
- Meta-analysisYu G, Xiang W, Zhang T, et al. (2020). Effectiveness of boswellia and boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies. DOI PubMed
- RCTSengupta K, Alluri KV, Satish AR, et al. (2008). A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Research & Therapy. DOI PubMed
- RCTSengupta K, Krishnaraju AV, Vishal AA, et al. (2010). Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee. International Journal of Medical Sciences. DOI PubMed
- Inprasit C, Bunyamahote S, Boonpattharatthiti K, Thimkorn P, et al. (2026). Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis.. Complementary therapies in medicine. DOI PubMed
- Dalmonte T, Andreani G, Rudelli C, Isani G (2024). Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis.. Phytotherapy research : PTR. DOI PubMed
- Meta-analysisDubey V, Kheni D, Sureja V (2024). Efficacy evaluation of standardized Boswellia serrata extract (AflapinⓇ) in osteoarthritis: A systematic review and sub-group meta-analysis study.. Explore (New York, N.Y.). DOI PubMed
- Meta-analysisBannuru RR, Osani MC, Al-Eid F, Wang C (2018). Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.. Seminars in arthritis and rheumatism. DOI PubMed
Show 5 more references
- Karimi M, Vakili K, Rashidian P, Razavi-Amoli SK, et al. (2024). Effect of boswellia (Boswellia serrata L.) supplementation on glycemic markers and lipid profile in type 2 diabetic patients: a systematic review and meta-analysis.. Frontiers in clinical diabetes and healthcare. DOI PubMed
- Basch E, Boon H, Davies-Heerema T, Foppo I, et al. (2004). Boswellia: an evidence-based systematic review by the Natural Standard Research Collaboration.. Journal of herbal pharmacotherapy. PubMed
- Vaidya N, Agarwal R, Dipankar DG, Patkar H, et al. (2025). Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial.. Pharmaceutical research. DOI PubMed
- Zhang Y, Gui Y, Adams R, Farragher J, et al. (2025). Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.. Nutrients. DOI PubMed
- Kumar B, Ghaytidak AB, Pandey AK, Somepalli RR, et al. (2025). A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.. Journal of the American Nutrition Association. DOI PubMed