General Dosage
25-50mg daily for adults over 40
Maximum dose: 50mg daily unless medically supervised (higher doses increase androgenic side effects)
DHEA Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 25-50mg daily for adults over 40
Timing: Morning to mimic natural diurnal cortisol/DHEA rhythm • Take with food for best absorption.
Dosage by Condition
Adrenal insufficiency
25-50mg dailyStrong
General anti-aging
25-50mg dailyModerate
Vaginal atrophy (intravaginal)
6.5mg nightlyStrong
Bone density support
50mg dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Adrenal insufficiency | 25-50mg daily | Strong |
| General anti-aging | 25-50mg daily | Moderate |
| Vaginal atrophy (intravaginal) | 6.5mg nightly | Strong |
| Bone density support | 50mg daily | Moderate |
Upper limit: 50mg daily unless medically supervised (higher doses increase androgenic side effects)
Timing & Absorption
Morning to mimic natural diurnal cortisol/DHEA rhythm
Best taken with food for optimal absorption.
References
- Arlt W, Callies F, van Vlijmen JC, Koehler I, Reincke M, Bidlingmaier M, Huebler D, Oettel M, Ernst M, Schulte HM, Allolio B (1999). Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine. DOI PubMed
- Labrie F, Archer DF, Koltun W, Vachon A, Young D, Frenette L, Portman D, Montesino M, Cote I, Parent J, Lavoie L, Beauregard A, Martel C, Vaillancourt M, Balser J, Bhatt E (2016). Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness. Menopause. DOI PubMed
- Jankowski CM, Gozansky WS, Schwartz RS, Dahl DJ, Kittelson JM, Scott SM, Van Pelt RE, Kohrt WM (2006). Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. Journal of Clinical Endocrinology & Metabolism. DOI PubMed