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Types of DHEA: Forms & Bioavailability

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Micronized DHEA CapsulesHighGeneral supplementation — well-absorbed oral form
DHEA Cream (Transdermal)ModerateTargeted delivery — may bypass first-pass liver metabolism
Intravaginal DHEA (Prasterone)High (local)Vaginal atrophy — FDA-approved indication

Micronized DHEA Capsules

Bioavailability: High. Best for: General supplementation — well-absorbed oral form.

DHEA Cream (Transdermal)

Bioavailability: Moderate. Best for: Targeted delivery — may bypass first-pass liver metabolism.

Intravaginal DHEA (Prasterone)

Bioavailability: High (local). Best for: Vaginal atrophy — FDA-approved indication.

Full DHEA Guide

References

  1. (). Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine. DOI
  2. (). Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness. Menopause. DOI
  3. (). Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. Journal of Clinical Endocrinology & Metabolism. DOI