General Dosage
25-50mg daily, adjusted based on DHEA-S blood levels
Maximum dose: 100mg daily has been used in clinical studies; doses above 50mg increase risk of hormonal side effects without proportional benefit
DHEA Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 25-50mg daily, adjusted based on DHEA-S blood levels
Timing: Morning to mimic natural circadian DHEA production pattern; with food • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Age-related DHEA decline (men over 40) | 25-50mg daily after baseline DHEA-S testing | Moderate |
| Body composition and visceral fat | 50mg daily | Moderate |
| Adrenal insufficiency | 25-50mg daily (prescription context) | Strong |
| Bone density support | 50mg daily long-term | Moderate |
Upper limit: 100mg daily has been used in clinical studies; doses above 50mg increase risk of hormonal side effects without proportional benefit
Timing & Absorption
Morning to mimic natural circadian DHEA production pattern; with food
Best taken with food for optimal absorption.
References
- Villareal DT, Holloszy JO (2004). Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. DOI PubMed
- Nair KS, Rizza RA, O'Brien P, et al. (2006). DHEA in elderly women and DHEA or testosterone in elderly men. New England Journal of Medicine. DOI PubMed
- Jankowski CM, Gozansky WS, Schwartz RS, et al. (2006). Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. Journal of Clinical Endocrinology and Metabolism. DOI PubMed