General Dosage
100-500mg daily with a fat-containing meal
Maximum dose: 2000mg/day (only in short intermittent protocols; not for daily use at this level)
Fisetin Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 100-500mg daily with a fat-containing meal
Timing: With a fatty meal for absorption; intermittent high-dose protocols mimic clinical trial designs • Take with food for best absorption.
Dosage by Condition
Daily antioxidant / longevity
100-500mg dailyEmerging
Senolytic protocol (intermittent)
1000-2000mg for 2 consecutive days per monthPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Daily antioxidant / longevity | 100-500mg daily | Emerging |
| Senolytic protocol (intermittent) | 1000-2000mg for 2 consecutive days per month | Preliminary |
Upper limit: 2000mg/day (only in short intermittent protocols; not for daily use at this level)
Timing & Absorption
With a fatty meal for absorption; intermittent high-dose protocols mimic clinical trial designs
Best taken with food for optimal absorption.
References
- Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI PubMed
- Currais A, Prior M, Dargusch R, et al. (2014). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI PubMed
- Zhu Y, Doornebal EJ, Pirtskhalava T, et al. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI PubMed