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Fisetin Dosage Guide

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

100-500mg daily with a fat-containing meal

Maximum dose: 2000mg/day (only in short intermittent protocols; not for daily use at this level)

Dosage Recommendations

General recommendation: 100-500mg daily with a fat-containing meal

Timing: With a fatty meal for absorption; intermittent high-dose protocols mimic clinical trial designs • Take with food for best absorption.

Dosage by Condition

Daily antioxidant / longevity
100-500mg dailyEmerging
Senolytic protocol (intermittent)
1000-2000mg for 2 consecutive days per monthPreliminary

Upper limit: 2000mg/day (only in short intermittent protocols; not for daily use at this level)

Timing & Absorption

With a fatty meal for absorption; intermittent high-dose protocols mimic clinical trial designs

Best taken with food for optimal absorption.

Full Fisetin Guide

References

  1. Zhu Y, Doornebal EJ, Pirtskhalava T, et al. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI PubMed
  2. ReviewAdeli OA, Heidari-Soureshjani S, Rostamian S, Azadegan-Dehkordi Z, et al. (2024). Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review.. Current pharmaceutical biotechnology. DOI PubMed
  3. ReviewJiang Y, Tang X, Deng P, Jiang C, et al. (2023). The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.. Molecular neurobiology. DOI PubMed
  4. Yamaura K, Nelson AL, Nishimura H, Rutledge JC, et al. (2022). The effects of fisetin on bone and cartilage: A systematic review.. Pharmacological research. DOI PubMed
  5. ReviewPrem PN, Sivakumar B, Boovarahan SR, Kurian GA (2022). Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.. Phytomedicine : international journal of phytotherapy and phytopharmacology. DOI PubMed
  6. Crocetto F, di Zazzo E, Buonerba C, Aveta A, et al. (2021). Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature.. Nutrients. DOI PubMed
  7. Kubina R, Iriti M, Kabała-Dzik A (2021). Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers.. Nutrients. DOI PubMed
Show 5 more references
  1. RCTAlipour M, Saeidi A, Hejazi K, Supriya R, et al. (2026). The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.. Nutrients. DOI PubMed
  2. Ji J, Crespi CM, Yee L, Zekster YA, et al. (2026). A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design.. Therapeutic advances in medical oncology. DOI PubMed
  3. Krishnakumar IM, Jaja-Chimedza A, Joseph A, Balakrishnan A, et al. (2022). Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.. Journal of nutritional science. DOI PubMed
  4. AnimalYousefzadeh MJ, Zhu Y, McGowan SJ, et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI PubMed
  5. Currais A, Prior M, Dargusch R, et al. (2014). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI PubMed