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Fisetin Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well-tolerated at standard doses
  • Mild GI discomfort at higher doses
  • Limited long-term human safety data
  • Theoretical concern about clearing beneficial senescent cells needed for wound healing

Drug & Supplement Interactions

  • Blood thinners — fisetin may have mild antiplatelet activity; use caution with anticoagulants
  • Chemotherapy — senolytics may interact with cancer treatment protocols; consult oncologist
  • CYP enzyme substrates — fisetin may modestly inhibit CYP3A4 and CYP1A2

Maximum Dose

Do not exceed: 2000mg/day (only in short intermittent protocols; not for daily use at this level)

Full Fisetin Guide

References

  1. Zhu Y, Doornebal EJ, Pirtskhalava T, et al. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI PubMed
  2. ReviewAdeli OA, Heidari-Soureshjani S, Rostamian S, Azadegan-Dehkordi Z, et al. (2024). Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review.. Current pharmaceutical biotechnology. DOI PubMed
  3. ReviewJiang Y, Tang X, Deng P, Jiang C, et al. (2023). The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.. Molecular neurobiology. DOI PubMed
  4. Yamaura K, Nelson AL, Nishimura H, Rutledge JC, et al. (2022). The effects of fisetin on bone and cartilage: A systematic review.. Pharmacological research. DOI PubMed
  5. ReviewPrem PN, Sivakumar B, Boovarahan SR, Kurian GA (2022). Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.. Phytomedicine : international journal of phytotherapy and phytopharmacology. DOI PubMed
  6. Crocetto F, di Zazzo E, Buonerba C, Aveta A, et al. (2021). Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature.. Nutrients. DOI PubMed
  7. Kubina R, Iriti M, Kabała-Dzik A (2021). Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers.. Nutrients. DOI PubMed
Show 5 more references
  1. RCTAlipour M, Saeidi A, Hejazi K, Supriya R, et al. (2026). The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.. Nutrients. DOI PubMed
  2. Ji J, Crespi CM, Yee L, Zekster YA, et al. (2026). A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design.. Therapeutic advances in medical oncology. DOI PubMed
  3. Krishnakumar IM, Jaja-Chimedza A, Joseph A, Balakrishnan A, et al. (2022). Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.. Journal of nutritional science. DOI PubMed
  4. AnimalYousefzadeh MJ, Zhu Y, McGowan SJ, et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI PubMed
  5. Currais A, Prior M, Dargusch R, et al. (2014). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI PubMed