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Fisetin Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well-tolerated at standard doses
  • Mild GI discomfort at higher doses
  • Limited long-term human safety data
  • Theoretical concern about clearing beneficial senescent cells needed for wound healing

Drug & Supplement Interactions

  • Blood thinners — fisetin may have mild antiplatelet activity; use caution with anticoagulants
  • Chemotherapy — senolytics may interact with cancer treatment protocols; consult oncologist
  • CYP enzyme substrates — fisetin may modestly inhibit CYP3A4 and CYP1A2

Maximum Dose

Do not exceed: 2000mg/day (only in short intermittent protocols; not for daily use at this level)

Full Fisetin Guide

References

  1. (). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI
  2. (). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI
  3. (). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI