Skip to main content
Supplement ScienceSupplementScience

Types of Fisetin: Forms & Bioavailability

Evidence:Emerging
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Fisetin CapsulesLow (poor water solubility)Standard supplementation — take with fat to enhance absorption
Liposomal FisetinHighEnhanced absorption — lipid encapsulation significantly improves bioavailability

Fisetin Capsules

Bioavailability: Low (poor water solubility). Best for: Standard supplementation — take with fat to enhance absorption.

Liposomal Fisetin

Bioavailability: High. Best for: Enhanced absorption — lipid encapsulation significantly improves bioavailability.

Full Fisetin Guide

References

  1. Zhu Y, Doornebal EJ, Pirtskhalava T, et al. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI PubMed
  2. ReviewAdeli OA, Heidari-Soureshjani S, Rostamian S, Azadegan-Dehkordi Z, et al. (2024). Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review.. Current pharmaceutical biotechnology. DOI PubMed
  3. ReviewJiang Y, Tang X, Deng P, Jiang C, et al. (2023). The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.. Molecular neurobiology. DOI PubMed
  4. Yamaura K, Nelson AL, Nishimura H, Rutledge JC, et al. (2022). The effects of fisetin on bone and cartilage: A systematic review.. Pharmacological research. DOI PubMed
  5. ReviewPrem PN, Sivakumar B, Boovarahan SR, Kurian GA (2022). Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.. Phytomedicine : international journal of phytotherapy and phytopharmacology. DOI PubMed
  6. Crocetto F, di Zazzo E, Buonerba C, Aveta A, et al. (2021). Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature.. Nutrients. DOI PubMed
  7. Kubina R, Iriti M, Kabała-Dzik A (2021). Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers.. Nutrients. DOI PubMed
Show 5 more references
  1. RCTAlipour M, Saeidi A, Hejazi K, Supriya R, et al. (2026). The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.. Nutrients. DOI PubMed
  2. Ji J, Crespi CM, Yee L, Zekster YA, et al. (2026). A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design.. Therapeutic advances in medical oncology. DOI PubMed
  3. Krishnakumar IM, Jaja-Chimedza A, Joseph A, Balakrishnan A, et al. (2022). Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.. Journal of nutritional science. DOI PubMed
  4. AnimalYousefzadeh MJ, Zhu Y, McGowan SJ, et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI PubMed
  5. Currais A, Prior M, Dargusch R, et al. (2014). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI PubMed