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He Shou Wu Side Effects & Safety

Evidence:Preliminary
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Caution Needed

Potential Side Effects

  • Hepatotoxicity — multiple case reports of liver injury, some severe (Lei et al., 2015 review identified 450+ cases in China)
  • GI discomfort (diarrhea, nausea, abdominal pain)
  • Skin rash
  • Numbness in extremities (rare)
  • Raw form has much higher risk than processed — NEVER use raw he shou wu orally as a tonic

Drug & Supplement Interactions

  • May cause liver injury — avoid combining with other hepatotoxic drugs or supplements
  • May interact with statins and other cholesterol-lowering medications
  • May affect CYP enzyme metabolism
  • May enhance effects of laxatives (raw form is a strong laxative)
  • Avoid with pre-existing liver disease

Maximum Dose

Do not exceed: 1000mg processed extract daily (err on lower side due to liver concerns)

Full He Shou Wu Guide

References

  1. ReviewLei X, Chen J, Ren J, et al. (2015). Liver damage associated with Polygonum multiflorum Thunb.: a systematic review of case reports and case series. Evidence-Based Complementary and Alternative Medicine. DOI PubMed
  2. ReviewSun YN, Cui L, Li W, et al. (2016). Promotion of neuroprotective effects of Polygonum multiflorum: a review of pharmacological activities and mechanisms. Chinese Journal of Integrative Medicine. DOI