General Dosage
3-6 g L-citrulline or 6-8 g citrulline malate 30-60 minutes before exercise
Maximum dose: 10 g/day L-citrulline has been used safely; GI discomfort may increase at higher doses
L-Citrulline Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 3-6 g L-citrulline or 6-8 g citrulline malate 30-60 minutes before exercise
Timing: 30-60 minutes before exercise; can also be taken daily for ongoing NO support
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Exercise performance | 6-8 g citrulline malate pre-workout | Strong |
| Blood flow/NO production | 3-6 g L-citrulline daily | Strong |
| Blood pressure support | 3-6 g daily | Moderate |
Upper limit: 10 g/day L-citrulline has been used safely; GI discomfort may increase at higher doses
Timing & Absorption
30-60 minutes before exercise; can also be taken daily for ongoing NO support
Can be taken with or without food.
References
- Trexler ET, Persky AM, Ryan ED, et al. (2019). Acute effects of citrulline supplementation on high-intensity strength and power performance: a systematic review and meta-analysis. Sports Medicine. DOI PubMed
- Schwedhelm E, Maas R, Freese R, et al. (2008). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology. DOI PubMed