Safety Profile
Overall safety rating: Generally Safe
L-Citrulline Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Very well tolerated
- Mild GI discomfort at high doses (>10 g)
- Rare headache from vasodilation
Drug & Supplement Interactions
- PDE5 inhibitors (Viagra, Cialis) — additive vasodilatory effects; may cause excessive blood pressure drop
- Blood pressure medications — may enhance hypotensive effects
- Nitrate medications — additive NO-mediated vasodilation
Maximum Dose
Do not exceed: 10 g/day L-citrulline has been used safely; GI discomfort may increase at higher doses
References
- Trexler ET, Persky AM, Ryan ED, et al. (2019). Acute effects of citrulline supplementation on high-intensity strength and power performance: a systematic review and meta-analysis. Sports Medicine. DOI PubMed
- Schwedhelm E, Maas R, Freese R, et al. (2008). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology. DOI PubMed