General Dosage
10-20mg daily with or without food
Maximum dose: 40mg/day (limited safety data above 20mg)
PQQ (Pyrroloquinoline Quinone) Dosage Guide
Evidence:Emerging
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Dosage Recommendations
General recommendation: 10-20mg daily with or without food
Timing: Morning with or without food; often combined with CoQ10
Dosage by Condition
Mitochondrial biogenesis
10-20mg dailyEmerging
Cognitive support
20mg dailyEmerging
Energy and fatigue
20mg dailyEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Mitochondrial biogenesis | 10-20mg daily | Emerging |
| Cognitive support | 20mg daily | Emerging |
| Energy and fatigue | 20mg daily | Emerging |
Upper limit: 40mg/day (limited safety data above 20mg)
Timing & Absorption
Morning with or without food; often combined with CoQ10
Can be taken with or without food.
References
- RCTItoh Y, Hine K, Miura H, et al. (2016). Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ) on cognitive functions. Advances in Experimental Medicine and Biology. DOI PubMed
- RCTHarris CB, Chowanadisai W, Mishchuk DO, et al. (2013). Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Journal of Nutritional Biochemistry. DOI PubMed
- In-vitroChowanadisai W, Bauerly KA, Tchaparian E, et al. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression. Journal of Biological Chemistry. DOI PubMed