General Dosage
10-20mg daily
Maximum dose: 40mg/day (limited safety data beyond this dose)
PQQ Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 10-20mg daily
Timing: Morning with or without food; combine with CoQ10 for synergistic effects
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Cognitive support | 20mg daily | Emerging |
| Mitochondrial biogenesis | 10-20mg daily | Emerging |
| Sleep quality | 20mg daily | Emerging |
Upper limit: 40mg/day (limited safety data beyond this dose)
Timing & Absorption
Morning with or without food; combine with CoQ10 for synergistic effects
Can be taken with or without food.
References
- Harris CB, Chowanadisai W, Mishchuk DO, et al. (2013). Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Journal of Nutritional Biochemistry. DOI PubMed
- Nakano M, Ubukata K, Yamamoto T, Yamaguchi H (2009). Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. Food Style 21.
- Chowanadisai W, Bauerly KA, Tchaparian E, et al. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. Journal of Biological Chemistry. DOI PubMed