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PQQ (Pyrroloquinoline Quinone) Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Well-tolerated at doses up to 20mg/day in clinical trials
  • Mild headache reported infrequently
  • Insomnia if taken late in the day
  • Rare GI discomfort

Drug & Supplement Interactions

  • No significant drug interactions identified
  • May enhance effects of other mitochondrial supplements (CoQ10, NMN)
  • Theoretical interaction with blood thinners due to redox activity — use caution

Maximum Dose

Do not exceed: 40mg/day (limited safety data above 20mg)

Full PQQ (Pyrroloquinoline Quinone) Guide

References

  1. RCTItoh Y, Hine K, Miura H, et al. (2016). Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ) on cognitive functions. Advances in Experimental Medicine and Biology. DOI PubMed
  2. RCTHarris CB, Chowanadisai W, Mishchuk DO, et al. (2013). Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Journal of Nutritional Biochemistry. DOI PubMed
  3. In-vitroChowanadisai W, Bauerly KA, Tchaparian E, et al. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression. Journal of Biological Chemistry. DOI PubMed