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Resveratrol Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Gastrointestinal discomfort (diarrhea, nausea, cramping) at doses >1g/day
  • Headache (uncommon)
  • May act as a phytoestrogen at high doses — relevance uncertain
  • Rare: insomnia if taken late in the day

Drug & Supplement Interactions

  • Anticoagulants — resveratrol has mild antiplatelet activity; monitor with warfarin or aspirin
  • CYP3A4/CYP1A2 substrates — resveratrol may inhibit these enzymes, affecting drug metabolism
  • Estrogen-sensitive conditions — high-dose resveratrol has weak estrogenic activity; discuss with oncologist if relevant

Maximum Dose

Do not exceed: Up to 1,500mg/day has been used in clinical trials; GI side effects increase above 1g/day

Full Resveratrol Guide

References

  1. (). Effect of resveratrol supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Clinical Therapeutics. DOI
  2. (). Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials. Obesity Reviews. DOI
  3. (). The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precision Oncology. DOI