Safety Profile
Overall safety rating: Generally Safe
Tribulus Terrestris Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally well tolerated at standard doses
- Mild GI discomfort (stomach cramps, nausea) in some users
- Rare: sleep disturbances reported anecdotally
- One case report of hepatotoxicity and nephrotoxicity at very high doses (causality uncertain)
Drug & Supplement Interactions
- Diabetes medications — tribulus may have mild blood sugar lowering effects; monitor if taking hypoglycemics
- Blood pressure medications — may have additive hypotensive effects
- Lithium — potential diuretic effect may alter lithium levels
Maximum Dose
Do not exceed: 1500 mg/day; higher doses do not overcome the lack of testosterone effect
References
- Neychev VK, Mitev VI (2005). The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. Journal of Ethnopharmacology. DOI PubMed
- Rogerson S, Riches CJ, Jennings C, et al. (2007). The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. Journal of Strength and Conditioning Research. DOI PubMed
- Santos CA Jr, Reis LO, Moreira MR, et al. (2014). Does the association of Tribulus terrestris and Cornus officinalis improve sexual function and seminal quality?. Actas Urologicas Espanolas. DOI PubMed