General Dosage
250-500mg daily for general liver support
Maximum dose: 1750mg/day (used in clinical trials without serious adverse effects)
TUDCA (Tauroursodeoxycholic Acid) Dosage Guide
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Dosage Recommendations
General recommendation: 250-500mg daily for general liver support
Timing: Take with meals, divided into 2-3 doses for higher dosages • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General liver protection | 250-500mg daily | Moderate |
| Cholestatic liver disease | 750-1500mg daily | Strong |
| Steroid/prohormone liver support | 500-1000mg daily | Emerging |
| Metabolic/insulin resistance support | 1500-1750mg daily | Emerging |
Upper limit: 1750mg/day (used in clinical trials without serious adverse effects)
Timing & Absorption
Take with meals, divided into 2-3 doses for higher dosages
Best taken with food for optimal absorption.
References
- Pan XL, Zhao L, Li L, Li AH, Ye J, Yang L, Xu KS, Hou XH (2013). Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: A double-blind randomized controlled trial. Journal of Huazhong University of Science and Technology - Medical Sciences. DOI PubMed
- Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS (2006). Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. DOI PubMed
- Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ (1998). A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Journal of Clinical Investigation. DOI PubMed
- Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S (2010). Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. DOI PubMed