Safety Profile
Overall safety rating: Generally Safe
TUDCA (Tauroursodeoxycholic Acid) Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Mild diarrhea (most common, especially at higher doses)
- Nausea or stomach discomfort
- Rare: constipation or flatulence
- Very rare: allergic skin reactions
Drug & Supplement Interactions
- May reduce absorption of cyclosporine — separate by 2 hours
- Bile acid sequestrants (cholestyramine, colestipol) reduce TUDCA absorption — separate by 4 hours
- May potentiate effects of other hepatoprotective agents
- Aluminum-containing antacids may reduce absorption
Maximum Dose
Do not exceed: 1750mg/day (used in clinical trials without serious adverse effects)
References
- Pan XL, Zhao L, Li L, Li AH, Ye J, Yang L, Xu KS, Hou XH (2013). Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: A double-blind randomized controlled trial. Journal of Huazhong University of Science and Technology - Medical Sciences. DOI PubMed
- Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS (2006). Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. DOI PubMed
- Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ (1998). A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Journal of Clinical Investigation. DOI PubMed
- Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S (2010). Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. DOI PubMed