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TUDCA (Tauroursodeoxycholic Acid) Side Effects & Safety

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Mild diarrhea (most common, especially at higher doses)
  • Nausea or stomach discomfort
  • Rare: constipation or flatulence
  • Very rare: allergic skin reactions

Drug & Supplement Interactions

  • May reduce absorption of cyclosporine — separate by 2 hours
  • Bile acid sequestrants (cholestyramine, colestipol) reduce TUDCA absorption — separate by 4 hours
  • May potentiate effects of other hepatoprotective agents
  • Aluminum-containing antacids may reduce absorption

Maximum Dose

Do not exceed: 1750mg/day (used in clinical trials without serious adverse effects)

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References

  1. RCTPan XL, Zhao L, Li L, Li AH, Ye J, Yang L, Xu KS, Hou XH (2013). Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: A double-blind randomized controlled trial. Journal of Huazhong University of Science and Technology - Medical Sciences. DOI PubMed
  2. ObservationalRodrigues CM, Fan G, Ma X, Kren BT, Steer CJ (1998). A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Journal of Clinical Investigation. DOI PubMed
  3. RCTKars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S (2010). Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. DOI PubMed