Integrative Therapeutics
Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.
Browse Products
Integrative Therapeutics Pro-Flora Concentrate
1 capsule per serving (90 capsules, 90 servings) per capsule · Proprietary Probiotic Blend (1 Billion CFUs) with True Delivery Technology Triple-Layer Coating
Clinical-grade probiotic supplement using Probiotic Pearls True Delivery Technology — a triple-layer coating system that protects 1 billion CFUs through gastric acid to maximize delivery to the lower intestine. Free from salt, wheat, soy, and artificial colors.
Integrative Therapeutics Pro-Biome
1 capsule per serving; 30 servings per bottle per capsule · 50 billion CFU proprietary 10-strain probiotic blend + prebiotics
Pro-Biome is a clinical-grade multi-strain probiotic from Integrative Therapeutics delivering 50 billion live cultures per serving across 10 probiotic strains, combined with prebiotics to support the survival and activity of the live bacteria. Designed for digestive health and immune function support, with the doctor-preferred Lactobacillus rhamnosus GG strain included for regularity support. Gluten-free, dairy-free, and manufactured under GMP standards since 1979.
IT Glutamine Forte Lemon Lime Powder
1 serving (scoop) per day (30 servings per container) per powder · L-Glutamine 5 g + Theracurmin (water-dispersible curcumin)
L-glutamine and Theracurmin drink mix delivering 5 g glutamine per serving to support gut barrier integrity and intestinal health.
IT Vitex Extract
1 capsule per serving (60 capsules, 60 servings) per capsule · Vitex agnus-castus extract (0.5% agnusides)
Standardized vitex (chaste tree berry) extract at 0.5% agnusides for premenstrual and menstrual cycle support. Vegan, gluten-free, dairy-free. 60 capsules.
IT Cellular Forte IP-6 & Inositol
2 capsules per serving (120 capsules, 60 servings) per capsule · IP-6 (Inositol Hexaphosphate) + Inositol
Inositol hexaphosphate (IP-6) and inositol capsule targeting natural killer cell activity and cellular immune function. Vegan, gluten-free, dairy-free.
Integrative Therapeutics Curalieve Curcumin Formula
2 capsules per serving (30 servings per bottle) per capsule · CurcuRouge amorphous curcumin
Integrative Therapeutics Curalieve uses CurcuRouge, a proprietary amorphous curcumin technology that delivers over 3x the bioavailability of submicron-particle colloidal dispersions. Founded in 1979, Integrative Therapeutics has supplied clinician-grade formulas to healthcare practitioners for over 25 years, and Curalieve reflects that heritage: manufactured in GMP-certified facilities, free of wheat, gluten, soy, dairy, and artificial flavors. Each serving of 2 capsules provides bioavailable curcuminoids designed to support antioxidant pathways and healthy inflammatory response at clinically meaningful concentrations.
Digestive Health & ProbioticsCapsuleIntegrative Therapeutics Enterogenic Intensive 100
1 capsule per serving, 30 servings per capsule · Multi-strain probiotic blend (Lactobacilli & Bifidobacteria, 100 billion CFU)
100 billion CFU, 10-strain enteric-coated probiotic designed for intensive GI support with aqueous coating that protects cultures through stomach acid.
Digestive SupportCapsuleIntegrative Therapeutics Heartburn Advantage
1 capsule per serving; 60 servings per bottle per capsule · Proprietary clinically-dosed GI blend (licorice root, zinc carnosine, melatonin, artichoke)
Heartburn Advantage is a clinician-formulated digestive supplement from Integrative Therapeutics that combines multiple researched-dose ingredients to support the gastrointestinal tract without suppressing stomach acid production. Designed to address occasional heartburn, bloating, and epigastric discomfort through mechanisms that support GI tract function rather than interfering with digestion. Manufactured under GMP standards since 1979.
Multivitamin SupplementsCapsuleIntegrative Therapeutics ProThrivers Wellness Multivitamin
Multi-nutrient blend per 2-capsule serving (60 capsules, 30 servings) per capsule · Vitamins A, C, D, B12 + Biotin + Zinc + Selenium + Iodine + Folate
Oncology-informed multivitamin formulated for cancer thrivers, including vitamins A, C, D, B12, biotin, zinc, selenium, iodine, and folate — with deliberate exclusions of beta-carotene, alpha-tocopherol, copper, and boron based on clinical oncology guidance.
Nootropic SupplementsCapsuleIntegrative Therapeutics ProThrivers Wellness Brain
Cognitive support blend per 2-capsule serving (120 capsules, 60 servings) per capsule · Theracurmin + Cognizin Citicoline + Lion's Mane Mushroom + Acetyl L-Carnitine
Oncology-informed brain health supplement blending Theracurmin bioavailable curcumin, Cognizin citicoline, lion's mane mushroom, and acetyl L-carnitine — developed under integrative oncology naturopathic guidance for cancer thriver cognitive support.
Men's HealthCapsuleIntegrative Therapeutics Testosterone Formula
3 capsules per serving (90 capsules, 30 servings per bottle) per capsule · Tribulus terrestris and Panax ginseng with ashwagandha
Integrative Therapeutics Testosterone Formula combines traditional botanical extracts — including Tribulus, ginseng, and ashwagandha — with essential nutrients to support healthy testosterone levels in active adult men. The vegetarian capsule formula is designed for those pursuing active lifestyles and looking for a practitioner-quality herbal approach to men's hormonal wellness. Integrative Therapeutics has delivered GMP-certified, clinician-trusted supplements since 1979. This product is explicitly not intended for women or children.
Probiotic SupplementsCapsuleIT Probiotic Pearls Advantage 5B CFU
5 billion CFU 4-strain blend per capsule (60 capsules, 60 servings) per capsule · L. plantarum + L. acidophilus + B. lactis + B. longum (5B CFU)
5 billion CFU, 4-strain probiotic (L. plantarum, L. acidophilus, B. lactis, B. longum) in a triple-layer True Delivery Technology capsule designed for shelf-stable intestinal delivery. Non-refrigerated. Clinical-grade Integrative Therapeutics formulation.
Antioxidant & Heart HealthSoftgelIT Resveratrol Ultra HP 175mg Softgels (60ct)
175mg resveratrol per softgel; once daily per softgel · Resveratrol 175mg + Rutin
60 once-daily softgels delivering 175mg resveratrol plus rutin for antioxidant and heart health support. Non-soy, gluten-free, dairy-free. 61 reviews at 4.6 stars.
CoQ10 SupplementsChewable TabletIntegrative Therapeutics Vitaline CoQ10 100 mg
100 mg CoQ10 per chewable tablet (30 tablets, 30 servings at 1 tablet/day) per chewable tablet · Coenzyme Q10 (CoQ10) 100 mg
Clinical-grade 100 mg chewable CoQ10 tablet in tropical fruit flavor from Integrative Therapeutics. Dairy-free, no artificial ingredients.
AntioxidantsCapsuleIT Glutathione Cell Defense 60ct
1 capsule per serving (60 servings per bottle) per capsule · Setria Reduced Glutathione 400 mg + AnthoRedoxin Botanical Blend (Beet Root, Bilberry, European Elderberry) + L-Cysteine
Clinical-grade Setria reduced glutathione paired with AnthoRedoxin botanical blend and L-cysteine for comprehensive cellular antioxidant defense.
Amino Acid SupplementsCapsuleIntegrative Therapeutics Acetyl L-Carnitine
Acetyl L-Carnitine per serving (60 capsules, 30 servings at 2 capsules/day) per capsule · Acetyl L-Carnitine
Clinical-grade acetyl-L-carnitine capsule from Integrative Therapeutics supporting brain energy and nerve function. Vegan, gluten-free, dairy-free.
Joint Support SupplementsCapsuleIntegrative Therapeutics Glucosamine Sulfate
Glucosamine sulfate per 3-capsule serving (240 capsules, 80 servings) per capsule · Glucosamine Sulfate
Clinical-grade glucosamine sulfate capsules from Integrative Therapeutics, providing the foundational building block for cartilage and connective tissue. Free of wheat, gluten, corn, soy, and dairy. Contains shellfish (crab and shrimp).
Brain & Neurological Support SupplementsSoftgelIntegrative Therapeutics Petadolex Butterbur Extract
Butterbur extract per 1-softgel serving (60 softgels, 60 servings) per softgel · Butterbur Extract (Petasites hybridus) — PA-free, standardized for petasin compounds
Patented PA-free butterbur (Petasites hybridus) extract in softgel form from Integrative Therapeutics, specifically processed to remove harmful pyrrolizidine alkaloids while retaining petasin compounds for blood vessel relaxation support in the brain. Gluten-free and dairy-free.
Cognitive Health & Brain FunctionCapsuleIntegrative Therapeutics Magtein L-Threonate Plus
3 capsules per serving (30 servings per bottle); recommended split as 1 capsule in the morning + 2 capsules 1 hour before bedtime per capsule · Magtein Magnesium L-Threonate
Integrative Therapeutics Magtein L-Threonate Plus combines Magtein — the patented magnesium L-threonate form developed by MIT researchers specifically to cross the blood-brain barrier — with vitamins C and D3 in a 3-capsule daily serving. Founded in 1979, Integrative Therapeutics brings over 25 years of GMP-certified, practitioner-trusted manufacturing to this cognitively targeted formula. Unlike conventional magnesium forms (citrate, oxide, glycinate) that primarily address muscle and bowel function, Magtein is the only magnesium form with human clinical evidence for increasing brain magnesium concentrations and supporting short-term memory, executive function, and cognitive flexibility. The formula is free of gluten, wheat, soy, dairy, gelatin, and artificial colors.
Antioxidant SupplementsCapsuleIntegrative Therapeutics ProThrivers Wellness Flavonoid Complex
Multi-compound antioxidant blend per serving (120 capsules) per capsule · CoQ10 + Theracurmin Curcumin + Green Tea Extract + L-Glutathione
Clinical-grade antioxidant complex formulated for cancer thrivers, combining CoQ10, Theracurmin curcumin extract, green tea extract, and L-glutathione in a dairy-free, gluten-free capsule designed under naturopathic guidance.
Berberine SupplementsCapsuleIntegrative Therapeutics Berberine Phytomax
Twice-daily capsule (60 capsules per bottle, 30 servings) per capsule · Berberine Phytosome (Berbevis, Indena)
Clinical-grade berberine using Indena's Berbevis Phytosome system — embedding berberine in a phospholipid matrix for 4× greater bioavailability than standard HCl. Twice-daily capsule supports lipid and carbohydrate metabolism, healthy body composition, and antioxidant pathways. GMP-certified, manufactured by Integrative Therapeutics (est. 1979).
Frequently Asked Questions
Do I need a doctor to buy Integrative Therapeutics products?
Do I need a doctor to buy Integrative Therapeutics products?
Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.
Is Integrative Therapeutics a reputable brand?
Is Integrative Therapeutics a reputable brand?
Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.
How does Cortisol Manager work and is it effective?
How does Cortisol Manager work and is it effective?
Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.
What is SBI Protect and who should take it?
What is SBI Protect and who should take it?
SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.
What is the difference between Integrative Therapeutics and typical store-brand supplements?
What is the difference between Integrative Therapeutics and typical store-brand supplements?
The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer





