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Science-Verified Brand

Integrative Therapeutics

Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.

Founded 1979Green Bay, Wisconsin93 products
Third-Party TestedNo Proprietary BlendsClinical DosingPublished COAs

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.

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All 93Digestive Enzymes 6Digestive Support 4Probiotic Supplements 3Omega-3 / Fish Oil 3Bone Health 2Immune Support 2CoQ10 Supplements 2Digestive Enzyme Supplements 2Respiratory Support 2Hormone & Aging Support 2Mineral Support 2Vitamin D Supplements 2Berberine Supplements 2Iron Supplements 1Vitamin C 1Multivitamins 1Women's Hormonal Health 1Liver Detox Support 1B Vitamins 1Mood & Sleep Support 1Vitamin B12 1Detox & Hormonal Support 1Digestive Fiber & Colon Support 1Antioxidants & Heart Health 1Stress & Sleep 1Men's Health 1Liver Support 1Brain & Nerve Health 1Heart & Energy Support 1Antioxidant & Immune Support 1Heart & Cellular Energy Support 1Antioxidant & Respiratory Support 1Stress Support 1Amino Acid Supplements 1B Vitamin Supplements 1Joint Support Supplements 1Brain & Neurological Support Supplements 1Brain & Cognitive Support 1Joint & Movement Support 1Digestive & Gut Health 1Sleep & Stress Support 1Digestive Health & Probiotics 1B-Complex Supplements 1Calcium Supplements 1Quercetin Supplements 1Adaptogen Supplements 1Sleep Supplements 1Antioxidant Supplements 1Multivitamin Supplements 1Turmeric Supplements 1Nootropic Supplements 1Hormone Balance Support 1Antioxidant & Heart Health 1Digestive & Colon Support 1Minerals 1Antioxidants 1Probiotics 1Amino Acids / Gut Health 1Gut Health / Zinc 1Bone Health / Minerals 1Iron Supplement 1Seasonal Immune Support 1GI Motility Support 1Adrenal & Stress Support 1Sleep Support 1Multivitamin 1Nootropic 1Zinc 1Probiotic 1Antioxidant & Anti-Inflammatory 1Bone & Cardiovascular Health 1Cognitive Health & Brain Function 1
Probiotic SupplementsCapsule

Integrative Therapeutics Pro-Flora Concentrate

GMP Certified

1 capsule per serving (90 capsules, 90 servings) per capsule · Proprietary Probiotic Blend (1 Billion CFUs) with True Delivery Technology Triple-Layer Coating

Clinical-grade probiotic supplement using Probiotic Pearls True Delivery Technology — a triple-layer coating system that protects 1 billion CFUs through gastric acid to maximize delivery to the lower intestine. Free from salt, wheat, soy, and artificial colors.

4.8 (108)
$55.00$0.61/serving
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ProbioticCapsule

Integrative Therapeutics Pro-Biome

GMP-manufactured, bottled and tested in the USA

1 capsule per serving; 30 servings per bottle per capsule · 50 billion CFU proprietary 10-strain probiotic blend + prebiotics

Pro-Biome is a clinical-grade multi-strain probiotic from Integrative Therapeutics delivering 50 billion live cultures per serving across 10 probiotic strains, combined with prebiotics to support the survival and activity of the live bacteria. Designed for digestive health and immune function support, with the doctor-preferred Lactobacillus rhamnosus GG strain included for regularity support. Gluten-free, dairy-free, and manufactured under GMP standards since 1979.

4.5 (104)
$37.75$1.26/serving
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Amino Acids / Gut HealthPowder

IT Glutamine Forte Lemon Lime Powder

Third-Party Tested

1 serving (scoop) per day (30 servings per container) per powder · L-Glutamine 5 g + Theracurmin (water-dispersible curcumin)

L-glutamine and Theracurmin drink mix delivering 5 g glutamine per serving to support gut barrier integrity and intestinal health.

4.7 (94)
$56.00$8.00/serving
Women's Hormonal HealthCapsule

IT Vitex Extract

GMP Certified

1 capsule per serving (60 capsules, 60 servings) per capsule · Vitex agnus-castus extract (0.5% agnusides)

Standardized vitex (chaste tree berry) extract at 0.5% agnusides for premenstrual and menstrual cycle support. Vegan, gluten-free, dairy-free. 60 capsules.

4.7 (85)
$27.50$0.46/serving
Immune SupportCapsule

IT Cellular Forte IP-6 & Inositol

GMP Certified

2 capsules per serving (120 capsules, 60 servings) per capsule · IP-6 (Inositol Hexaphosphate) + Inositol

Inositol hexaphosphate (IP-6) and inositol capsule targeting natural killer cell activity and cellular immune function. Vegan, gluten-free, dairy-free.

4.6 (84)
$31.75$0.26/serving
Antioxidant & Anti-InflammatoryCapsule

Integrative Therapeutics Curalieve Curcumin Formula

Third-Party Tested

2 capsules per serving (30 servings per bottle) per capsule · CurcuRouge amorphous curcumin

Integrative Therapeutics Curalieve uses CurcuRouge, a proprietary amorphous curcumin technology that delivers over 3x the bioavailability of submicron-particle colloidal dispersions. Founded in 1979, Integrative Therapeutics has supplied clinician-grade formulas to healthcare practitioners for over 25 years, and Curalieve reflects that heritage: manufactured in GMP-certified facilities, free of wheat, gluten, soy, dairy, and artificial flavors. Each serving of 2 capsules provides bioavailable curcuminoids designed to support antioxidant pathways and healthy inflammatory response at clinically meaningful concentrations.

4.6 (81)
$66.25$1.10/serving
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Integrative Therapeutics Enterogenic Intensive 100 CapsuleDigestive Health & ProbioticsCapsule

Integrative Therapeutics Enterogenic Intensive 100

Third-Party Tested

1 capsule per serving, 30 servings per capsule · Multi-strain probiotic blend (Lactobacilli & Bifidobacteria, 100 billion CFU)

100 billion CFU, 10-strain enteric-coated probiotic designed for intensive GI support with aqueous coating that protects cultures through stomach acid.

4.1 (77)
$53.50$1.78/serving
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Integrative Therapeutics Heartburn Advantage CapsuleDigestive SupportCapsule

Integrative Therapeutics Heartburn Advantage

GMP-manufactured, bottled and tested in the USA

1 capsule per serving; 60 servings per bottle per capsule · Proprietary clinically-dosed GI blend (licorice root, zinc carnosine, melatonin, artichoke)

Heartburn Advantage is a clinician-formulated digestive supplement from Integrative Therapeutics that combines multiple researched-dose ingredients to support the gastrointestinal tract without suppressing stomach acid production. Designed to address occasional heartburn, bloating, and epigastric discomfort through mechanisms that support GI tract function rather than interfering with digestion. Manufactured under GMP standards since 1979.

4.5 (75)
$67.00$1.12/serving
Integrative Therapeutics ProThrivers Wellness Multivitamin CapsuleMultivitamin SupplementsCapsule

Integrative Therapeutics ProThrivers Wellness Multivitamin

GMP Certified

Multi-nutrient blend per 2-capsule serving (60 capsules, 30 servings) per capsule · Vitamins A, C, D, B12 + Biotin + Zinc + Selenium + Iodine + Folate

Oncology-informed multivitamin formulated for cancer thrivers, including vitamins A, C, D, B12, biotin, zinc, selenium, iodine, and folate — with deliberate exclusions of beta-carotene, alpha-tocopherol, copper, and boron based on clinical oncology guidance.

4.6 (68)
$49.75$0.83/serving
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Integrative Therapeutics ProThrivers Wellness Brain CapsuleNootropic SupplementsCapsule

Integrative Therapeutics ProThrivers Wellness Brain

GMP Certified

Cognitive support blend per 2-capsule serving (120 capsules, 60 servings) per capsule · Theracurmin + Cognizin Citicoline + Lion's Mane Mushroom + Acetyl L-Carnitine

Oncology-informed brain health supplement blending Theracurmin bioavailable curcumin, Cognizin citicoline, lion's mane mushroom, and acetyl L-carnitine — developed under integrative oncology naturopathic guidance for cancer thriver cognitive support.

4.5 (68)
$64.25$0.54/serving
Integrative Therapeutics Testosterone Formula CapsuleMen's HealthCapsule

Integrative Therapeutics Testosterone Formula

Third-Party Tested

3 capsules per serving (90 capsules, 30 servings per bottle) per capsule · Tribulus terrestris and Panax ginseng with ashwagandha

Integrative Therapeutics Testosterone Formula combines traditional botanical extracts — including Tribulus, ginseng, and ashwagandha — with essential nutrients to support healthy testosterone levels in active adult men. The vegetarian capsule formula is designed for those pursuing active lifestyles and looking for a practitioner-quality herbal approach to men's hormonal wellness. Integrative Therapeutics has delivered GMP-certified, clinician-trusted supplements since 1979. This product is explicitly not intended for women or children.

4.2 (64)
$42.50$0.47/serving
IT Probiotic Pearls Advantage 5B CFU CapsuleProbiotic SupplementsCapsule

IT Probiotic Pearls Advantage 5B CFU

GMP Certified

5 billion CFU 4-strain blend per capsule (60 capsules, 60 servings) per capsule · L. plantarum + L. acidophilus + B. lactis + B. longum (5B CFU)

5 billion CFU, 4-strain probiotic (L. plantarum, L. acidophilus, B. lactis, B. longum) in a triple-layer True Delivery Technology capsule designed for shelf-stable intestinal delivery. Non-refrigerated. Clinical-grade Integrative Therapeutics formulation.

4.2 (62)
$65.75$1.10/serving
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IT Resveratrol Ultra HP 175mg Softgels (60ct) SoftgelAntioxidant & Heart HealthSoftgel

IT Resveratrol Ultra HP 175mg Softgels (60ct)

GMP Certified

175mg resveratrol per softgel; once daily per softgel · Resveratrol 175mg + Rutin

60 once-daily softgels delivering 175mg resveratrol plus rutin for antioxidant and heart health support. Non-soy, gluten-free, dairy-free. 61 reviews at 4.6 stars.

4.6 (61)
$49.50$0.82/serving
Integrative Therapeutics Vitaline CoQ10 100 mg Chewable TabletCoQ10 SupplementsChewable Tablet

Integrative Therapeutics Vitaline CoQ10 100 mg

GMP Certified

100 mg CoQ10 per chewable tablet (30 tablets, 30 servings at 1 tablet/day) per chewable tablet · Coenzyme Q10 (CoQ10) 100 mg

Clinical-grade 100 mg chewable CoQ10 tablet in tropical fruit flavor from Integrative Therapeutics. Dairy-free, no artificial ingredients.

4.0 (51)
$33.75$1.13/serving
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IT Glutathione Cell Defense 60ct CapsuleAntioxidantsCapsule

IT Glutathione Cell Defense 60ct

Third-Party Tested

1 capsule per serving (60 servings per bottle) per capsule · Setria Reduced Glutathione 400 mg + AnthoRedoxin Botanical Blend (Beet Root, Bilberry, European Elderberry) + L-Cysteine

Clinical-grade Setria reduced glutathione paired with AnthoRedoxin botanical blend and L-cysteine for comprehensive cellular antioxidant defense.

4.7 (48)
$120.75$2.01/serving
Integrative Therapeutics Acetyl L-Carnitine CapsuleAmino Acid SupplementsCapsule

Integrative Therapeutics Acetyl L-Carnitine

GMP Certified

Acetyl L-Carnitine per serving (60 capsules, 30 servings at 2 capsules/day) per capsule · Acetyl L-Carnitine

Clinical-grade acetyl-L-carnitine capsule from Integrative Therapeutics supporting brain energy and nerve function. Vegan, gluten-free, dairy-free.

4.6 (47)
$40.50$0.68/serving
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Integrative Therapeutics Glucosamine Sulfate CapsuleJoint Support SupplementsCapsule

Integrative Therapeutics Glucosamine Sulfate

GMP Certified

Glucosamine sulfate per 3-capsule serving (240 capsules, 80 servings) per capsule · Glucosamine Sulfate

Clinical-grade glucosamine sulfate capsules from Integrative Therapeutics, providing the foundational building block for cartilage and connective tissue. Free of wheat, gluten, corn, soy, and dairy. Contains shellfish (crab and shrimp).

4.5 (47)
$57.75$0.96/serving
Integrative Therapeutics Petadolex Butterbur Extract SoftgelBrain & Neurological Support SupplementsSoftgel

Integrative Therapeutics Petadolex Butterbur Extract

GMP Certified

Butterbur extract per 1-softgel serving (60 softgels, 60 servings) per softgel · Butterbur Extract (Petasites hybridus) — PA-free, standardized for petasin compounds

Patented PA-free butterbur (Petasites hybridus) extract in softgel form from Integrative Therapeutics, specifically processed to remove harmful pyrrolizidine alkaloids while retaining petasin compounds for blood vessel relaxation support in the brain. Gluten-free and dairy-free.

3.9 (35)
$61.00$1.02/serving
Integrative Therapeutics Magtein L-Threonate Plus CapsuleCognitive Health & Brain FunctionCapsule

Integrative Therapeutics Magtein L-Threonate Plus

Third-Party Tested

3 capsules per serving (30 servings per bottle); recommended split as 1 capsule in the morning + 2 capsules 1 hour before bedtime per capsule · Magtein Magnesium L-Threonate

Integrative Therapeutics Magtein L-Threonate Plus combines Magtein — the patented magnesium L-threonate form developed by MIT researchers specifically to cross the blood-brain barrier — with vitamins C and D3 in a 3-capsule daily serving. Founded in 1979, Integrative Therapeutics brings over 25 years of GMP-certified, practitioner-trusted manufacturing to this cognitively targeted formula. Unlike conventional magnesium forms (citrate, oxide, glycinate) that primarily address muscle and bowel function, Magtein is the only magnesium form with human clinical evidence for increasing brain magnesium concentrations and supporting short-term memory, executive function, and cognitive flexibility. The formula is free of gluten, wheat, soy, dairy, gelatin, and artificial colors.

4.9 (29)
$42.00$0.47/serving
Integrative Therapeutics ProThrivers Wellness Flavonoid Complex CapsuleAntioxidant SupplementsCapsule

Integrative Therapeutics ProThrivers Wellness Flavonoid Complex

GMP Certified

Multi-compound antioxidant blend per serving (120 capsules) per capsule · CoQ10 + Theracurmin Curcumin + Green Tea Extract + L-Glutathione

Clinical-grade antioxidant complex formulated for cancer thrivers, combining CoQ10, Theracurmin curcumin extract, green tea extract, and L-glutathione in a dairy-free, gluten-free capsule designed under naturopathic guidance.

4.4 (24)
$67.25$0.56/serving
Integrative Therapeutics Berberine Phytomax CapsuleBerberine SupplementsCapsule

Integrative Therapeutics Berberine Phytomax

GMP Certified

Twice-daily capsule (60 capsules per bottle, 30 servings) per capsule · Berberine Phytosome (Berbevis, Indena)

Clinical-grade berberine using Indena's Berbevis Phytosome system — embedding berberine in a phospholipid matrix for 4× greater bioavailability than standard HCl. Twice-daily capsule supports lipid and carbohydrate metabolism, healthy body composition, and antioxidant pathways. GMP-certified, manufactured by Integrative Therapeutics (est. 1979).

4.6 (22)
$41.00$0.68/serving
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Frequently Asked Questions

Do I need a doctor to buy Integrative Therapeutics products?

Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.

Is Integrative Therapeutics a reputable brand?

Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.

How does Cortisol Manager work and is it effective?

Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.

What is SBI Protect and who should take it?

SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.

What is the difference between Integrative Therapeutics and typical store-brand supplements?

The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer