Integrative Therapeutics
Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.
Browse Products
IT V Clear EPs 7630 Cherry Syrup (4 oz)
Proprietary homeopathic preparation per serving; 4 oz bottle per liquid · Pelargonium sidoides 1X (EPs 7630)
Cherry-flavored 4 oz liquid with Pelargonium sidoides EPs 7630, clinically studied in 20+ trials for upper respiratory comfort during the common cold.
IT Rhizinate Sugarless DGL Chewable
2-3 chewable tablets per serving (100 tablets, approximately 33 servings) per chewable · Deglycyrrhizinated Licorice (DGL)
Fructose-free chewable DGL (deglycyrrhizinated licorice) tablet supporting digestive comfort and protective factors in the GI tract. Contains less than 1% glycyrrhizin.
Integrative Therapeutics Vitamin E
1 softgel daily (60 softgels per bottle, 60 servings) per softgel · Mixed tocopherol vitamin E complex (alpha, gamma, beta, and delta tocopherols)
Integrative Therapeutics Vitamin E delivers the full tocopherol family — alpha, gamma, beta, and delta — rather than the isolated alpha-tocopherol found in most commodity vitamin E supplements. This mixed-tocopherol approach more closely mirrors the full-spectrum vitamin E found in whole foods. The cardiovascular and antioxidant applications of mixed tocopherols have strong mechanistic support, and Integrative Therapeutics' practitioner-grade GMP manufacturing since 1979 ensures product integrity. Each softgel serving is dairy-free and gluten-free with no artificial additives.
IT Magnesium Glycinate Plus 120ct
2 tablets per serving (60 servings per bottle) per tablet · Magnesium Bisglycinate / Malate Blend
Clinical-grade magnesium bisglycinate and malate blend from a practitioner brand with 25+ years of formulation trust.
Integrative Therapeutics Motility Activator
1 capsule twice daily; 60 servings per bottle per capsule · Artichoke Leaf Extract + Ginger Root Extract (patented combination)
Clinician-grade capsule formula combining standardized artichoke leaf extract with ginger root extract using a patented combination to support gastrointestinal motility and transport. 60 capsules, 1 capsule twice daily. Dairy-free, gluten-free, corn-free, soy-free. GMP-manufactured by Integrative Therapeutics since 1979.
Integrative Therapeutics Lipotropic Complex
2 capsules per serving (90 capsules per bottle, 45 servings) per capsule · Milk thistle (silymarin), choline, and methylcobalamin (B12)
Lipotropic Complex is Integrative Therapeutics' comprehensive liver support formula, combining methyl-donor nutrients (choline, methionine, folate, vitamins B6 as pyridoxal-5'-phosphate and B12 as methylcobalamin) with milk thistle's silymarin, and additional botanicals including dandelion root, fringe tree, beet root, and black radish. The lipotropic compounds support hepatic transmethylation reactions — a key liver detoxification pathway — while silymarin provides antioxidant and cell-protective support. Ox bile is included to support digestive fat emulsification and bile flow. Integrative Therapeutics has manufactured this practitioner-grade, GMP-certified formula since 1979.
Integrative Therapeutics Clinical Nutrients HP
2 capsules per day (30-day supply from 60-count bottle) per capsule · Theracurmin (curcumin) + beta-carotene + vitamins C & E
Clinical Nutrients HP is a comprehensive, iron-free multivitamin formulated by Integrative Therapeutics for men and women. Each serving delivers key micronutrients including beta-carotene, vitamins C and E, and Theracurmin — a highly bioavailable curcumin — for antioxidant and foundational nutritional support. Manufactured under GMP standards and tested in the USA.
Integrative Therapeutics Liquid Iron
Iron, B12, and folate per serving (exact mg per label); 35 servings per 6 fl oz bottle per liquid · Liquid Iron + Vitamin B12 + Folate
Apple cinnamon–flavored liquid iron supplement combining elemental iron with vitamin B12 and folate in a single 6 fl oz bottle (35 servings). Clinically positioned for hemoglobin formation, oxygen transport, and energy. No sugar, gluten, dairy, soy, corn, or animal-origin ingredients. GMP-manufactured since 1979.
IT DHEA-25 25mg Capsules (60ct)
25mg DHEA per capsule; 1 capsule daily per capsule · DHEA (dehydroepiandrosterone) 25mg
60 capsules of 25mg DHEA for healthy aging and adrenal hormone balance support. 462 reviews at 4.7 stars. Vegan, gluten-free, dairy-free from Integrative Therapeutics.
Integrative Therapeutics Panplex 2-Phase
2 tablets per serving (180 count, 90 servings) per tablet · Betaine HCl + Pepsin (Phase I) + Pancreatic Enzymes — Protease, Lipase, Amylase (Phase II)
Clinical-grade two-phase digestive enzyme tablet combining betaine HCl and pepsin for stomach-phase digestion with pancreatic enzymes for upper intestinal digestion. Gluten-free, designed for comprehensive digestive support across the full GI process.
IT Magnesium Malate 100mg Capsules (90ct)
100mg elemental magnesium per capsule (as magnesium malate) per capsule · Magnesium Malate 100mg elemental magnesium
90 capsules of magnesium malate delivering 100mg elemental magnesium each for cellular metabolism, bone health, and muscle function support.
Integrative Therapeutics Phosphatidylserine
1 softgel per serving, 60 servings per softgel · Phosphatidylserine (sunflower-derived)
Soy-free phosphatidylserine from sunflower lecithin supports memory, concentration, and cortisol stress response in clinical-grade softgels.
Integrative Therapeutics Iron Complex
Iron complex per 2-softgel serving (90 softgels, 45 servings) per softgel · Iron + Vitamin C + B12 + Folate
Clinical-grade iron softgel with vitamin C, folate, B12, and liquid liver fractions for hemoglobin support and energy. Gluten and dairy-free.
IT OsteoPrime Ultra Bone Support
4 tablets daily (120 tablets, 30 servings) per tablet · Calcium complex + Vitamin D + Magnesium + Zinc + Vitamin C
Comprehensive bone support tablet with multiple calcium forms, vitamin D, C, zinc, niacin, and magnesium for calcium absorption and bone structure.
IT Krebs Magnesium-Potassium Complex (120ct / 60srv)
2 tablets per serving; 60 servings per 120-count bottle per tablet · Magnesium + Potassium (citrate and malate forms)
120 tablets of magnesium and potassium complexed to Krebs cycle intermediates (citrate and malate) for heart muscle and cellular energy support. 412 reviews, 4.7 stars.
IT CoQ10 100mg Softgels (60ct)
100mg CoQ10 per softgel; 1 softgel three times daily (300mg/day) per softgel · Coenzyme Q10 100mg
60 softgels delivering 100mg CoQ10 per serving for cellular energy, heart, and brain health support from Integrative Therapeutics' clinical-grade line.
Integrative Therapeutics K2 + D3
1 capsule per serving (60 servings per bottle) per capsule · MenaQ7 Vitamin K2 (MK-7) + Vitamin D3 (cholecalciferol)
Integrative Therapeutics K2 + D3 combines MenaQ7 — the most clinically studied vitamin K2 (MK-7) ingredient on the market — with high-potency vitamin D3 (cholecalciferol) in a single daily vegetarian capsule. Founded in 1979, Integrative Therapeutics has earned the trust of healthcare practitioners across more than 25 years of GMP-certified formulation. This combination targets the calcium utilization cascade: D3 enhances intestinal calcium absorption, while MenaQ7 K2 activates osteocalcin (directing calcium into bone) and Matrix Gla Protein (protecting arteries from calcium deposits). The result is synergistic support for bone strength and arterial flexibility, addressing a gap left by D3-only supplementation.
Integrative Therapeutics AllQlear
2 chewable tablets per serving; 30 servings per 60-tablet bottle per chewable tablet · Stragen Quail Egg Powder (ovomucoids as tryptase inhibitor)
Berry-flavored chewable tablet delivering a proprietary Stragen quail egg powder blend containing ovomucoids that act as tryptase inhibitors to support healthy mast cell stabilization. Dairy-free, 60 chewable tablets per bottle (30 servings). GMP-manufactured by Integrative Therapeutics since 1979.
Integrative Therapeutics OsteoPrime Forte
4 capsules daily with a meal (can be split as 2 capsules twice daily with a meal) per capsule · Multi-form calcium complex (calcium citrate and four additional calcium forms)
OsteoPrime Forte is Integrative Therapeutics' comprehensive bone-health formula, combining five forms of calcium alongside vitamin D, magnesium, zinc, vitamins C, B6, and B12, and vitamin K. Designed to support skeletal integrity and musculoskeletal function, the multi-calcium approach is intended to optimize absorption across different physiological pathways. Integrative Therapeutics has been a practitioner-trusted, GMP-certified brand since 1979, and OsteoPrime Forte reflects that clinical-grade standard — free of wheat, gluten, soy, dairy, and artificial additives.
IT Rhizinate DGL Chewable
3 chewable tablets per serving (100 tablets, approximately 33 servings) per chewable · Deglycyrrhizinated Licorice (DGL)
Chewable DGL (deglycyrrhizinated licorice) tablet for soothing digestive comfort and GI protective factor support. Contains less than 1% glycyrrhizin. 100 tablets.
Integrative Therapeutics Alpha-Glycosyl Isoquercitrin
1 capsule daily (60 capsules, 60 servings) per capsule · Alpha-Glycosyl Isoquercitrin (bioavailable quercetin)
Clinical-grade bioavailable quercetin supplement using alpha-glycosyl isoquercitrin — an enzymatically modified quercetin form with significantly enhanced water solubility and intestinal absorption. Supports antioxidant pathways, healthy glutathione levels, and cellular integrity. Vegan and dairy-free.
IT EHB Immune Complex Capsules (60ct / 20srv)
3 capsules per serving; 20 servings per 60-count bottle per capsule · Echinacea + Goldenseal + Oregon Grape + Garlic + Vitamins A, C, B6 + Zinc
Multi-herb immune complex combining echinacea, goldenseal, Oregon grape, garlic, licorice, ginger with vitamins A, C, B6, and zinc. 60 capsules, 20 servings. 339 reviews, 4.8 stars.
IT Similase Sensitive Stomach (90ct)
2 capsules per serving (90 capsules, 45 servings) per capsule · Microbial digestive enzymes + Marshmallow + Slippery Elm + Licorice Root + Gamma-Oryzanol
Microbial digestive enzymes plus soothing botanicals (marshmallow, slippery elm, licorice root, gamma-oryzanol) for sensitive stomach GI support. Vegan, dairy-free.
Integrative Therapeutics Vitamin D3 2000 IU Chewable
2,000 IU (50 mcg) cholecalciferol per chewable tablet (120 tablets, 120 servings at 1 tablet/day) per chewable tablet · Vitamin D3 (Cholecalciferol) 2,000 IU (50 mcg)
Clinical-grade 2,000 IU vitamin D3 chewable tablet in chocolate flavor from Integrative Therapeutics for bone health and immune support. Gluten and dairy-free.
Frequently Asked Questions
Do I need a doctor to buy Integrative Therapeutics products?
Do I need a doctor to buy Integrative Therapeutics products?
Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.
Is Integrative Therapeutics a reputable brand?
Is Integrative Therapeutics a reputable brand?
Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.
How does Cortisol Manager work and is it effective?
How does Cortisol Manager work and is it effective?
Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.
What is SBI Protect and who should take it?
What is SBI Protect and who should take it?
SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.
What is the difference between Integrative Therapeutics and typical store-brand supplements?
What is the difference between Integrative Therapeutics and typical store-brand supplements?
The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer























