Integrative Therapeutics Phosphatidylserine - Brain Function Support Supplement* - Supports Healthy Stress Response* - Gluten-Free, Soy-Free & Dairy-Free - 60 Softgels (60 Servings)

Clinical trials typically use 100-300mg daily. Integrative Therapeutics Phosphatidylserine delivers 1 softgel per serving, 60 servings, which we classify as Blend relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Softgel vs alternatives), dose adequacy, and third-party testing.

Yes — Third-Party Tested. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Phosphatidylserine may have mild interactions with blood thinners and anticholinergic medications — consult your physician before use if you're on these drugs. It may also modestly affect cortisol levels, so those on corticosteroid therapies should exercise caution. At standard doses (100-300mg/day), interactions are generally considered low risk.

Long-term use of phosphatidylserine at clinical doses has been studied up to 6 months with good tolerability in healthy adults and older individuals. Mild gastrointestinal discomfort (nausea, stomach upset) is the most commonly reported side effect at higher doses. This formulation is derived from sunflower lecithin, which has a cleaner safety profile than earlier bovine-source PS.

Most users tolerate phosphatidylserine softgels without digestive issues when taken with food. A small subset of users report mild stomach upset, especially at doses above 200mg. Taking this with a meal reduces the likelihood of GI discomfort.

Phosphatidylserine stacks well with omega-3 fatty acids, which may enhance its membrane-supporting properties in the brain. It can also be combined with B-complex vitamins, L-theanine, and bacopa without known adverse interactions. Avoid combining with large doses of blood-thinning supplements like high-dose fish oil or nattokinase without medical oversight.

Take with food to minimize any potential GI discomfort. Standard dosing is 100-300mg/day, typically split across 1-3 servings. Avoid taking late in the evening as PS may mildly stimulate mental alertness in some individuals. Consult a healthcare provider if pregnant, nursing, or managing a chronic condition.

Clinical research on phosphatidylserine typically shows measurable cognitive benefits after 4-12 weeks of consistent daily use. Stress-response improvements (cortisol blunting) can begin to emerge in as little as 2-4 weeks at therapeutic doses. Casual supplementation at lower doses may take longer to produce noticeable effects.