Jarrow Formulas PS 100: Are there any potential interactions with medications?

Jarrow Formulas PS 100 contains phosphatidylserine, which may interact with blood-thinning medications and cholinergic drugs. The 100mg dose can affect neurotransmitter balance. Consult your doctor if taking anticoagulants, antidepressants, or Alzheimer's medications (acetylcholinesterase inhibitors).

Jarrow Formulas PS 100: Are there any side effects from long-term use?

Phosphatidylserine has a strong safety record with studies running 6-12 months. Jarrow uses Cogni-PS, a soy-free branded ingredient with guaranteed potency. The FDA allows a qualified health claim for PS and cognitive decline risk reduction. Safe for long-term daily use.

Jarrow Formulas PS 100: Does it cause any digestive issues or side effects?

Most users tolerate PS 100 well. The softgel format with sunflower oil carrier enhances absorption of this fat-soluble phospholipid. Occasional reports of mild GI discomfort or insomnia at higher doses (300mg+). Start with 100mg and increase gradually.

Jarrow Formulas PS 100: Can it be taken with other supplements or vitamins?

PS pairs well with omega-3 fish oil (both support brain cell membranes), B vitamins, and other cognitive supplements. The phospholipid form complements choline sources like alpha-GPC. Can be taken with most daily vitamins and minerals.

Jarrow Formulas PS 100: Are there any specific instructions for taking it safely?

Take 1 softgel 1-3 times daily with meals containing fat for optimal absorption. The clinical dose is 300mg daily (3 softgels). Start with 100mg and increase as needed. The Cogni-PS branded ingredient ensures soy-free, consistent potency.

Jarrow Formulas PS 100: How long until benefits are typically experienced?

Cognitive benefits from phosphatidylserine typically emerge after 6-12 weeks of consistent daily use at 100-300mg. Memory and concentration improvements are gradual. Clinical studies typically run 12 weeks to demonstrate significant effects.

Jarrow Formulas PS 100: Is the dosage suitable for meeting daily requirements?

Each softgel provides exactly 100mg of phosphatidylserine — matching the per-dose amount used in clinical studies. The typical clinical protocol is 100mg three times daily (300mg total). One softgel provides adequate maintenance dosing; three softgels match the full clinical dose.

Jarrow Formulas PS 100: Are there specific instructions for taking it with food?

Take with meals containing dietary fat for optimal absorption. Phosphatidylserine is a fat-soluble phospholipid — the softgel format with sunflower oil carrier already enhances absorption, but food further improves bioavailability. Morning, noon, and evening with meals for the 3x daily protocol.

Jarrow Formulas PS 100: How long does one bottle typically last when used daily?

The 120-count bottle provides 120 servings at 1 softgel per day (4 months) or 40 servings at 3 softgels per day (about 6 weeks for the full clinical dose). At $54.79, this is $0.46/day (1 softgel) or $1.37/day (3 softgels).

Jarrow Formulas PS 100: Is its dosage easy to adjust for individual needs?

The 100mg softgel allows flexible dosing from 100-300mg daily. Take 1 for maintenance, 2 for moderate support, or 3 for the full clinical dose. Softgels cannot be easily split, but the 100mg increment matches clinical protocols perfectly.

Jarrow Formulas PS 100: Is the product tested for purity and potency?

Jarrow Formulas states the product is third-party tested. The Cogni-PS branded ingredient provides guaranteed potency and batch-to-batch consistency. Soy-free, sunflower-derived sourcing eliminates soy allergen concerns. Jarrow Formulas has been manufacturing since 1977.

Jarrow Formulas PS 100: Does it contain any fillers, binders, or artificial ingredients?

Contains Cogni-PS phosphatidylserine, sunflower oil, softgel (gelatin, glycerin, water), and sunflower lecithin. No artificial colors, flavors, or preservatives. The sunflower oil serves as both a carrier and absorption enhancer for the fat-soluble PS.

Jarrow Formulas PS 100: Does it contain any allergens or additives?

Soy-free (Cogni-PS is sunflower-derived). Contains gelatin (softgel shell — not vegan). Free from gluten, dairy, and nuts. Contains sunflower-derived ingredients. No artificial ingredients. Suitable for most allergy profiles except gelatin sensitivity.

Jarrow Formulas PS 100: Are the ingredients sourced from trusted suppliers?

Jarrow Formulas uses Cogni-PS, a premium branded phosphatidylserine from Enzymotec (now Frutarom/IFF). Cogni-PS is sunflower-derived with guaranteed phosphatidylserine concentration. Jarrow is a trusted supplement manufacturer with decades of phospholipid expertise.

Jarrow Formulas PS 100: Is its potency consistent across batches?

With over 680 Amazon reviews and a 4.3-star average, Jarrow PS 100 demonstrates reliable quality. The Cogni-PS branded ingredient ensures supply chain consistency. Jarrow Formulas has been manufacturing phospholipid supplements for decades.

Jarrow Formulas PS 100: Does it help with focus and mental clarity?

Phosphatidylserine is a key component of brain cell membranes and supports neurotransmitter function. Clinical studies show improvements in memory, concentration, and cognitive processing speed at 100-300mg daily. The FDA allows a qualified health claim for PS and cognitive decline.

Jarrow Formulas PS 100: How effective is it for sustained energy without jitters?

PS is not a stimulant. It supports cognitive function by maintaining brain cell membrane integrity and facilitating neurotransmitter release. Some studies show PS can modulate cortisol response to stress, which may improve mental endurance without any stimulant effects.

Jarrow Formulas PS 100: Is its effectiveness backed by scientific research?

Phosphatidylserine is backed by extensive clinical research. Glade & Smith (2015) reviewed its effects on cognition. Kato-Kataoka et al. (2010) demonstrated memory improvements. The FDA allows a qualified health claim — rare for dietary supplements. The Cogni-PS form matches clinical study specifications.

Jarrow Formulas PS 100: What do customers think of its effectiveness?

Customers report improvements in memory, focus, and stress management with consistent use. The most common feedback is gradual but noticeable cognitive improvement after 6-12 weeks. The softgel format is praised for ease of use. Some note the need for 3 softgels daily for full clinical dose adds cost.

Jarrow Formulas PS 100: Are the capsules/tablets easy to swallow?

The softgels are standard supplement size and easy to swallow with the smooth gelatin coating. Only 1 softgel per single dose. Taking 3 daily for the full clinical dose requires commitment but each individual softgel is manageable.

Jarrow Formulas PS 100: Is its formulation suitable for long-term use?

Yes. Phosphatidylserine is a natural component of cell membranes and is safe for long-term supplementation. The FDA qualified health claim supports the role of PS in long-term cognitive health. Jarrow has offered PS supplements for many years.

Jarrow Formulas PS 100: Does it require special storage conditions?

Store in a cool, dry place away from direct sunlight. No refrigeration required but keeping in a cool environment maintains the phospholipid integrity. The softgel format protects the PS from oxidation. Keep tightly sealed.

Jarrow Formulas PS 100: Is it suitable for individuals with dietary restrictions?

Soy-free (sunflower-derived). Gluten-free. Contains gelatin (not vegan). Free from dairy, nuts, and artificial ingredients. Suitable for most dietary patterns except vegan/strict vegetarian due to gelatin softgel.

Jarrow Formulas PS 100: Are the capsules vegetarian/vegan?

No. The softgel contains gelatin, which is animal-derived. Not suitable for vegans or strict vegetarians. For a vegan PS option, choose a vegetable capsule format. The PS ingredient itself (Cogni-PS) is plant-derived from sunflower.

Jarrow Formulas PS 100: Is its formulation non-GMO?

The Cogni-PS phosphatidylserine is sunflower-derived, avoiding GMO soy concerns. Jarrow Formulas does not prominently advertise a specific non-GMO certification for this product. Sunflower is inherently less likely to be GMO than soy.

Double Wood PhosphatidylSerine 300mg: Is Double Wood PhosphatidylSerine 300mg safe for daily use?

Yes, phosphatidylserine has a strong safety profile backed by extensive clinical research. Double Wood PS is NSF Certified, which is rare for PS supplements and provides independent verification of purity and potency. The FDA allows a qualified health claim for PS and cognitive decline.

Double Wood PhosphatidylSerine 300mg: Can Double Wood PS interact with blood thinners or medications?

Phosphatidylserine may interact with blood-thinning medications and cholinergic drugs used for Alzheimer's treatment. The 300mg dose can affect neurotransmitter balance. Consult your doctor before combining with anticoagulants, antidepressants, or acetylcholinesterase inhibitors.

Double Wood PhosphatidylSerine 300mg: Are there side effects from Double Wood PhosphatidylSerine?

Most users tolerate PS well. Occasional reports include mild digestive discomfort or insomnia at higher doses. The 2-capsule serving allows you to start with just 150mg (1 capsule) and increase gradually to the full 300mg dose to assess tolerance.

Double Wood PhosphatidylSerine 300mg: Does Double Wood PS contain allergens?

This product uses soy-derived phosphatidylserine, which may not be suitable for those with soy allergies. It is NSF Certified for purity. If soy is a concern, consider sunflower-derived alternatives like Jarrow Formulas PS 100 with Cogni-PS.

Double Wood PhosphatidylSerine 300mg: Can I take Double Wood PS long-term for brain health?

Phosphatidylserine is a natural component of brain cell membranes and is considered safe for long-term daily supplementation. Clinical studies have run 6-12 months without safety concerns. The FDA qualified health claim supports the role of PS in long-term cognitive health.

Double Wood PhosphatidylSerine 300mg: How many Double Wood PS capsules should I take daily?

The full clinical dose is 300mg per serving, which requires 2 capsules (150mg each). Most cognitive studies use 300mg daily. You can start with 1 capsule (150mg) to assess tolerance before increasing to the full 2-capsule serving.

Double Wood PhosphatidylSerine 300mg: When should I take Double Wood PhosphatidylSerine?

Take with meals containing dietary fat for optimal absorption, as PS is a fat-soluble phospholipid. Many users split the dose: 1 capsule with breakfast and 1 with lunch. Avoid taking PS close to bedtime, as some users report mild alertness that may affect sleep.

Double Wood PhosphatidylSerine 300mg: Should I take Double Wood PS with food?

Yes, always take with meals containing some dietary fat. Phosphatidylserine is fat-soluble, and food significantly improves absorption. Taking with a meal that includes eggs, nuts, avocado, or olive oil will enhance bioavailability of the PS.

Double Wood PhosphatidylSerine 300mg: How long does it take for Double Wood PS to show results?

Cognitive benefits from phosphatidylserine typically emerge after 6-12 weeks of consistent daily use at 300mg. Memory and concentration improvements are gradual and cumulative. Clinical studies typically run 12 weeks to demonstrate significant cognitive effects.

Double Wood PhosphatidylSerine 300mg: How long does one bottle of Double Wood PS last?

The bottle contains 120 capsules. At the full 300mg dose (2 capsules daily), one bottle lasts 60 days. At a maintenance dose of 150mg (1 capsule daily), it lasts 120 days. At $20.95 per bottle, this provides strong value for an NSF-certified product.

Double Wood PhosphatidylSerine 300mg: What is the NSF certification on Double Wood PS?

NSF Certification means the product has been independently tested by NSF International for purity, potency, and label accuracy. This is rare for phosphatidylserine supplements and provides extra assurance that the product contains what the label claims, free from contaminants.

Double Wood PhosphatidylSerine 300mg: Is Double Wood PS soy-derived or sunflower-derived?

Double Wood PS is soy-derived. Soy-derived phosphatidylserine has the longest clinical track record, as most landmark cognition studies used soy PS. However, those with soy allergies should choose a sunflower-derived alternative.

Double Wood PhosphatidylSerine 300mg: Does Double Wood PS contain any fillers or artificial ingredients?

Double Wood Supplements is known for their clean, straightforward formulations with minimal filler ingredients. The product contains phosphatidylserine as the active ingredient in vegetarian capsules. NSF Certification independently verifies the formulation integrity.

Double Wood PhosphatidylSerine 300mg: How does Double Wood PS compare to Jarrow Formulas PS 100?

Double Wood delivers 300mg per serving (full clinical dose) while Jarrow provides 100mg per softgel. Double Wood is NSF Certified and soy-derived with 13,800+ reviews. Jarrow uses branded Cogni-PS (soy-free, sunflower-derived) in softgels. Double Wood offers better value; Jarrow offers allergen-free sourcing.

Double Wood PhosphatidylSerine 300mg: What are the active compounds in phosphatidylserine?

Phosphatidylserine is a phospholipid concentrated in brain cell membranes. It consists of a glycerol backbone, two fatty acids, and a serine head group. PS facilitates neurotransmitter release, supports cell membrane fluidity, and may modulate cortisol levels under stress.

Double Wood PhosphatidylSerine 300mg: Does Double Wood PS actually improve memory and focus?

Phosphatidylserine has substantial clinical evidence for cognitive support. Multiple studies show improvements in memory, concentration, and processing speed at 100-300mg daily. The FDA allows a qualified health claim for PS and cognitive decline risk reduction, which is rare for dietary supplements.

Double Wood PhosphatidylSerine 300mg: Is Double Wood PS effective for cortisol reduction?

Some clinical studies suggest phosphatidylserine can modulate the cortisol response to physical and mental stress. At 300mg daily (which this product provides), PS may blunt excessive cortisol spikes during exercise and stressful situations, supporting both cognitive and physical recovery.

Double Wood PhosphatidylSerine 300mg: What do customer reviews say about Double Wood PS?

With nearly 13,800 reviews and a 4.3-star average, Double Wood PS has massive consumer validation. Users commonly report gradual improvements in memory, focus, and mental clarity after 6-12 weeks. The NSF certification and value pricing are frequently cited positives.

Double Wood PhosphatidylSerine 300mg: How does Double Wood PS compare to other cognitive supplements?

PS targets a unique mechanism: brain cell membrane integrity. Unlike stimulant-based nootropics, PS builds structural brain support over time. Combined with its cortisol-modulating effects, it complements other nootropics like citicoline and omega-3s rather than competing with them.

Double Wood PhosphatidylSerine 300mg: Are the Double Wood PS capsules easy to swallow?

The capsules are standard supplement size. You need 2 capsules per serving for the full 300mg dose. Some users prefer products that deliver 300mg in a single capsule or softgel, but the 2-capsule format allows easy dose adjustment between 150mg and 300mg.

Double Wood PhosphatidylSerine 300mg: How should I store Double Wood PS?

Store in a cool, dry place away from direct sunlight and moisture. Phosphatidylserine supplements do not require refrigeration. Keep the bottle tightly sealed between uses to maintain potency throughout the shelf life.

Double Wood PhosphatidylSerine 300mg: What is the container size for Double Wood PS?

The bottle contains 120 capsules, weighing approximately 0.12 pounds. This provides 60 servings at the full 2-capsule dose (300mg) or 120 servings at the maintenance 1-capsule dose (150mg). The compact bottle is easy to store and travel with.

Best Phosphatidylserine Supplements (2026)

· Updated April 2026

Lab Tested, Evidence Ranked

Supplement Science Editorial Team·Evidence-Based Supplement Research

Published Mar 11, 2026·Reviewed Apr 24, 2026

2,400+Clinical Studies Cited

5Phosphatidylserine products evaluated

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Our Verdict

The best phosphatidylserine supplement delivers 100mg per capsule from sunflower-derived sources, ideally using branded ingredients like SerinAid or Sharp-PS.

Best By Category

#1Best Overall

Jarrow Formulas PS 100

Buy Nowon Amazon

#5Best Value

NOW Foods Phosphatidylserine 100mg

Buy Nowon Amazon

#4Best Branded Ingredient

Doctor's Best Phosphatidylserine with SerinAid

Buy Nowon Amazon

#1 Top Pick

Staff Pick

PS 100

Jarrow Formulas

686 Amazon reviews

9.1/10

4.3

Uses Cogni-PS — a soy-free, sunflower-derived branded phosphatidylserine with guaranteed potency. Softgel format enhances absorption of this fat-soluble phospholipid. Exact 100mg clinical dose per softgel allows flexible 1-3x daily dosing. Jarrow Formulas is a leader in phospholipid supplements.

IngredientPhosphatidylserine (Cogni-PS, soy-free)

Dose100mg phosphatidylserine per softgel

FormSoftgel

TestingThird-Party Tested

100mg phosphatidylserine per softgelClinical range: 100-300mg daily

Therapeutic dose

$0.90/serving$53.96 · 120 Softgels

Pros

Cogni-PS branded ingredient (soy-free)
Softgel for fat-soluble absorption
Exact 100mg clinical dose

Cons

Premium price vs generic PS
Three softgels daily for 300mg dose

Buy Nowon Amazon

Read full review →

The best phosphatidylserine supplement provides 100-300mg daily from sunflower (soy-free) sources, ideally using...

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We evaluated phosphatidylserine supplements across dose per capsule, source (sunflower vs soy), branded ingredient use, third-party testing, and value. Our picks prioritize the clinically studied 100mg dose with allergen-friendly sourcing.

As an Amazon Associate, we earn from qualifying purchases. Some links below are affiliate links — this doesn't affect our editorial independence or product ratings. How we evaluate products

Quick Comparison

#1Jarrow Formulas PS 100

9.1/10

Jarrow Formulas

#1 Top Pick

686 Amazon reviews

Best for: Overall best phosphatidylserine for cognitive support

Phosphatidylserine (Cogni-PS, soy-free) · 100mg phosphatidylserine per softgel

Softgel · Third-Party Tested

$53.96

$0.90/serving

Buy Nowon Amazon

#2Double Wood PhosphatidylSerine 300mg

8.6/10

Double Wood Supplements

13,822 Amazon reviews

Best for: NSF-certified phosphatidylserine at the full clinical dose with massive review validation

Phosphatidylserine (PS) · 300mg PS per serving (2 capsules)

Capsules · NSFNSF Certified, Third-Party Tested

$20.95

$0.17/serving

Buy Nowon Amazon

#3Integrative Therapeutics Phosphatidylserine

7.8/10

Integrative Therapeutics

443 Amazon reviews

Best for: Adults seeking soy-free brain and stress support from a clinical-grade phosphatidylserine derived from sunflower

Phosphatidylserine (sunflower-derived) · 1 softgel per serving, 60 servings

Softgel · Third-Party Tested

$49.25

$0.82/serving

Buy Nowon Amazon

#4Doctor's Best Phosphatidylserine with SerinAid

8.8/10

Doctor's BEST

633 Amazon reviews

Best for: phosphatidylserine with the most clinically studied branded ingredient

Phosphatidylserine (SerinAid) · 100mg phosphatidylserine per softgel

Softgel · Third-Party Tested

$29.99

$0.50/serving

Buy Nowon Amazon

#5NOW Foods Phosphatidylserine 100mg

8.6/10

NOW Foods

919 Amazon reviews

Best for: value phosphatidylserine

Phosphatidylserine (soy-free) · 100mg phosphatidylserine per capsule

Veg Capsule · GMP Certified, Third-Party Tested

$37.99

$0.63/serving

Buy Nowon Amazon

#	Product	Best For	Ingredient & Dose	Form & Testing	Price	Rating
1	Jarrow Formulas PS 100 #1 Top Pick 686 Amazon reviews	Overall best phosphatidylserine for cognitive support	Phosphatidylserine (Cogni-PS, soy-free) 100mg phosphatidylserine per softgel	Softgel 120 Softgels Third-Party Tested	$53.96 $0.90/serving	9.1/10	Buy Nowon Amazon
2	Double Wood PhosphatidylSerine 300mg 13,822 Amazon reviews	NSF-certified phosphatidylserine at the full clinical dose with massive review validation	Phosphatidylserine (PS) 300mg PS per serving (2 capsules)	Capsules 120 Capsules NSFNSF Certified, Third-Party Tested	$20.95 $0.17/serving	8.6/10	Buy Nowon Amazon
3	Integrative Therapeutics Phosphatidylserine 443 Amazon reviews	Adults seeking soy-free brain and stress support from a clinical-grade phosphatidylserine derived from sunflower	Phosphatidylserine (sunflower-derived) 1 softgel per serving, 60 servings	Softgel 60 Count Third-Party Tested	$49.25 $0.82/serving	7.8/10	Buy Nowon Amazon
4	Doctor's Best Phosphatidylserine with SerinAid 633 Amazon reviews	phosphatidylserine with the most clinically studied branded ingredient	Phosphatidylserine (SerinAid) 100mg phosphatidylserine per softgel	Softgel Third-Party Tested	$29.99 $0.50/serving	8.8/10	Buy Nowon Amazon
5	NOW Foods Phosphatidylserine 100mg 919 Amazon reviews	value phosphatidylserine	Phosphatidylserine (soy-free) 100mg phosphatidylserine per capsule	Veg Capsule GMP Certified, Third-Party Tested	$37.99 $0.63/serving	8.6/10	Buy Nowon Amazon

How We Chose These Products

We scored every contender on the 4weighted criteria below. Evidence quality and third-party verification carry the most weight; value, clean-label formulation, and transparency round out the score. Where tradeoffs appear — a higher-evidence form that costs more, a research-grade dose in a product with a heavier price tag, a commodity ingredient at a rock-bottom price — the pick that wins on evidence-grade criteria takes the top slot. Business partnerships never move a product's score, and lower-cost non-affiliate alternatives are included when they meet the same evidence bar.

Dose per Capsule

30%

Clinical studies use 100-300mg daily, typically as 100mg 3x/day. Products delivering 100mg per capsule allow flexible dosing and match the clinical protocol. Lower doses require more capsules and cost more per effective dose.

Source Material

25%

Sunflower-derived phosphatidylserine is allergen-friendly and avoids soy concerns. Soy-derived PS was the original source and is well-studied but may not suit those with soy allergies or sensitivities.

Branded Ingredient

25%

Branded ingredients like SerinAid (from soy) and Sharp-PS (from sunflower) provide batch-to-batch consistency and traceability. They indicate the manufacturer invested in verified raw materials rather than commodity-grade phospholipids.

Third-Party Testing

20%

Independent verification of phosphatidylserine content and purity. Important because phospholipid supplements can vary in composition and PS concentration.

Detailed Reviews

#1 Top Pick

Jarrow Formulas PS100 Phosphatidylserine 100mg, Dietary Supplement for Brain Health and Cognitive Function Support, 120 Softgels, Up to a 40-120 Day Supply

Jarrow Formulas

686 Amazon reviews

9.1/10

(686)

IngredientPhosphatidylserine (Cogni-PS, soy-free)

Dose100mg phosphatidylserine per softgel

FormSoftgel

TestingThird-Party Tested

100mg phosphatidylserine per softgelClinical range: 100-300mg daily

Therapeutic dose

$0.90/serving$53.96 · 120 Softgels

Ideal for: Overall best phosphatidylserine for cognitive support

Not ideal for: Those seeking the cheapest per-capsule price.

Pros

Cogni-PS branded ingredient (soy-free)
Softgel for fat-soluble absorption
Exact 100mg clinical dose
Trusted Jarrow Formulas brand

Cons

Premium price vs generic PS
Three softgels daily for 300mg dose
Sunflower-derived (fine for most, but noted)

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Read full Phosphatidylserine (Cogni-PS, soy-free)guide →

Double Wood PhosphatidylSerine 300mg — view 1 of 5

PhosphatidylSerine Supplement 300mg Per Serving, 120 Capsules (Phosphatidyl Serine Complex) by Double Wood

Double Wood Supplements

13,822 Amazon reviews

8.6/10

(13,822)

NSF Certified — rare for PS supplements — with nearly 14,000 reviews at 4.3 stars. The 300mg per serving matches the clinical dose used in cognitive studies. Double Wood is one of the most trusted value brands in the nootropic space.

IngredientPhosphatidylserine (PS)

Dose300mg PS per serving (2 capsules)

FormCapsules

TestingNSF Certified, Third-Party Tested

300mg PS per serving (2 capsules)Clinical range: 100-300mg daily

Therapeutic dose

$0.17/serving$20.95 · 120 Capsules

Ideal for: NSF-certified phosphatidylserine at the full clinical dose with massive review validation

Not ideal for: Those wanting a single-capsule serving (this requires 2 capsules for 300mg)

Pros

NSF Certified for purity
300mg full clinical dose
13,800+ reviews — massive validation
Competitive pricing

Cons

2 capsules needed per dose
Soy-derived (not sunflower)
4.3 stars slightly below premium brands

Buy Nowon Amazon

Read full Phosphatidylserine (PS)guide →

Integrative Therapeutics Phosphatidylserine - Brain Function Support Supplement* - Supports Healthy Stress Response* - Gluten-Free, Soy-Free & Dairy-Free - 60 Softgels (60 Servings)

Integrative Therapeutics

443 Amazon reviews

7.8/10

(443)

Free of gluten, soy, dairy, artificial colorsDerived from sunflower oil

Integrative Therapeutics has supplied practitioners since 1979 under GMP-certified manufacturing. Their sunflower-derived PS avoids the soy allergy concern that affects most competitors, and the clean allergen profile makes it accessible to a wider patient population. For anyone already working with a practitioner on cognitive or HPA-axis support, this is a trustworthy clinical-grade choice.

IngredientPhosphatidylserine (sunflower-derived)

Dose1 softgel per serving, 60 servings

FormSoftgel

TestingThird-Party Tested

1 softgel per serving, 60 servingsClinical range: 100-300mg daily

Blend formula

$0.82/serving$49.25 · 60 Count

Ideal for: Adults seeking soy-free brain and stress support from a clinical-grade phosphatidylserine derived from sunflower

Not ideal for: Budget shoppers or those needing very high-dose PS above 100mg per softgel

Pros

Soy-free phosphatidylserine derived from sunflower lecithin — no common allergen risk
Clinical-grade manufacturing with 25+ years of practitioner trust behind Integrative Therapeutics
Supports both cognitive function and cortisol stress response — dual mechanism
Clean label: no salt, wheat, gluten, soy, dairy, or artificial colors

Cons

Individual dose not explicitly stated on Amazon listing — requires label verification
Premium price point at ~$49 for 60 softgels vs mass-market PS options
Moderate review volume (443) limits confidence in real-world effectiveness data

Buy Nowon Amazon

Read full Phosphatidylserine (sunflower-derived)guide →

Doctor's Best Phosphatidylserine Supplement 100 mg - Phosphatidyl Serine Capsules for Men & Women, Memory & Cognitive Support for Adults, Supports Brain Health, Gluten Free, Vegan - 120 Veg Caps

Doctor's BEST

633 Amazon reviews

8.8/10

(633)

Uses SerinAid — the most clinically studied branded phosphatidylserine ingredient, used in many of the landmark PS cognition studies. Soy-derived SerinAid has the longest track record of safety and efficacy data. Softgel format with lipid base for optimal absorption.

IngredientPhosphatidylserine (SerinAid)

Dose100mg phosphatidylserine per softgel

FormSoftgel

TestingThird-Party Tested

100mg phosphatidylserine per softgelClinical range: 100-300mg daily

Therapeutic dose

$0.50/serving

Ideal for: phosphatidylserine with the most clinically studied branded ingredient

Not ideal for: Those with soy allergies (SerinAid is soy-derived) or seeking the lowest price.

Pros

SerinAid (most clinically studied PS)
Softgel with lipid base
Longest safety/efficacy track record
Full 100mg clinical dose

Cons

Soy-derived (allergen concern)
Premium price ($0.28/serving)
Soy-based in a sunflower-trending market

Buy Nowon Amazon

Read full Phosphatidylserine (SerinAid)guide →

NOW Foods Supplements, Phosphatidyl Serine 100 mg with Phospholipid compound derived from Soy Lecithin, 120 Veg Capsules

NOW Foods

919 Amazon reviews

8.6/10

(919)

Delivers the clinical 100mg dose at the lowest price per serving in the category. Soy-free formulation. GMP-certified manufacturing and third-party tested. NOW Foods consistently delivers quality at the best value. Veg capsule suits vegetarians.

IngredientPhosphatidylserine (soy-free)

Dose100mg phosphatidylserine per capsule

FormVeg Capsule

TestingGMP Certified, Third-Party Tested

100mg phosphatidylserine per capsuleClinical range: 100-300mg daily

Therapeutic dose

$0.63/serving

Ideal for: value phosphatidylserine

Not ideal for: Those wanting a softgel with lipid base or branded ingredient.

Pros

Best value at $0.20/serving
Soy-free formula
GMP certified
Full 100mg clinical dose

Cons

Veg capsule (no lipid base)
No branded ingredient
Take with food for absorption

Buy Nowon Amazon

Read full Phosphatidylserine (soy-free)guide →

Pairs Well With

Frequently taken together based on complementary benefits

Ashwagandha

Ritual Stress Relief Ashwagandha

1 capsule daily with extended-release delivery

(280)$1.44/serving

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L-Theanine

Sports Research Suntheanine L-Theanine 200mg

200mg Suntheanine per softgel

(14,982)$0.33/serving

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How to Choose

Phosphatidylserine (PS) is a phospholipid concentrated in brain cell membranes. The clinical dose for cognitive support is 100-300mg daily, with most studies using 300mg (100mg three times daily). Choose products delivering exactly 100mg per capsule for easy dose matching. Sunflower-derived PS is the modern standard (soy-free, allergen-friendly), though soy-derived PS (like SerinAid) has the longest clinical track record. PS is fat-soluble, so softgels with a lipid base absorb better than dry capsules — or take capsules with a fat-containing meal. Look for branded ingredients (Cogni-PS, SerinAid, Sharp-PS) that guarantee batch-to-batch consistency.

Ready to Buy?

Jarrow Formulas PS 100

9.1/10$0.90/servingBest for: Overall best phosphatidylserine for cognitive support

The best phosphatidylserine supplement delivers 100mg per capsule from sunflower-derived sources, ideally using branded ingredients like SerinAid or Sharp-PS.

Evidence:RCT (2010) · n=78 · moderate confidence[#2]

Buy Nowon Amazon

Read Our Full Phosphatidylserine Research Guide

Evidence level, dosage, side effects, and more →

Already taking supplements?

Check how Phosphatidylserine fits with your current stack — interactions, timing, and optimization →

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Frequently Asked Questions

How much phosphatidylserine should I take for memory?

The clinical dose is 100-300mg daily, with most studies using 300mg divided as 100mg three times daily with meals. Start with 100mg daily and increase to 300mg if needed. Benefits typically appear after 6-12 weeks of consistent use. Take with fat-containing meals for better absorption.

Evidence:RCT (2010) · n=78 · moderate confidence[#2]

Is soy-derived or sunflower-derived phosphatidylserine better?

Both sources are effective. Soy-derived PS (like SerinAid) has the longest clinical track record — most landmark cognition studies used soy PS. Sunflower-derived PS is the modern standard, avoiding soy allergen concerns. There is no evidence that one source produces superior cognitive benefits over the other.

How long does phosphatidylserine take to improve memory?

Most studies show measurable cognitive improvements after 6-12 weeks of consistent 100-300mg daily supplementation. Memory and attention effects tend to plateau around the 3-month mark, suggesting the benefits require sustained use rather than occasional dosing.

Are there side effects from phosphatidylserine?

Phosphatidylserine is well-tolerated at typical doses. Higher doses (600mg+) may cause mild insomnia or stomach upset. Soy-derived PS is safe for most, but people with severe soy allergies should choose sunflower-derived alternatives.

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References

ReviewGlade MJ, Smith K (2015). Phosphatidylserine and the human brain. Nutrition. DOI PubMed
RCTKato-Kataoka A, Sakai M, Ebina R, et al. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed