We evaluated phosphatidylserine supplements across dose per capsule, source (sunflower vs soy), branded ingredient use, third-party testing, and value. Our picks prioritize the clinically studied 100mg dose with allergen-friendly sourcing.
Best Phosphatidylserine Supplements (2026)
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Our Verdict
The best phosphatidylserine supplement delivers 100mg per capsule from sunflower-derived sources, ideally using branded ingredients like SerinAid or Sharp-PS.
Best By Category
TL;DR — Quick Answer
The best phosphatidylserine for most people is a 100mg sunflower-derived capsule taken 3x daily (300mg total). Jarrow Formulas PS 100 with Cogni-PS is our top pick for its branded ingredient and value. The clinical dose for cognitive support is 100-300mg daily, with most studies using 300mg.
Our recommendations are based on published research, not commission rates. Some links below are affiliate links — we may earn a commission at no extra cost to you. How we evaluate products
3+ products evaluated · Ratings based on published research, not commissions
Quick Comparison
#1Jarrow Formulas PS 100
9.1/10
Jarrow Formulas
Best for: Overall best phosphatidylserine for cognitive support
Phosphatidylserine (Cogni-PS, soy-free) · 100mg phosphatidylserine per softgel
Softgel · Third-Party Tested
$0.25
#2NOW Foods Phosphatidylserine 100mg
8.6/10
NOW Foods
Best for: Best value phosphatidylserine
Phosphatidylserine (soy-free) · 100mg phosphatidylserine per capsule
Veg Capsule · GMP Certified, Third-Party Tested
$0.20
#3Doctor's Best Phosphatidylserine with SerinAid
8.8/10
Doctor's Best
Best for: Best phosphatidylserine with the most clinically studied branded ingredient
Phosphatidylserine (SerinAid) · 100mg phosphatidylserine per softgel
Softgel · Third-Party Tested
$0.28
| # | Product | Best For | Ingredient & Dose | Form & Testing | Price | Rating | |
|---|---|---|---|---|---|---|---|
| 1 | Jarrow Formulas PS 100 Jarrow Formulas | Overall best phosphatidylserine for cognitive support | Phosphatidylserine (Cogni-PS, soy-free) 100mg phosphatidylserine per softgel | Softgel Third-Party Tested | $0.25 | 9.1/10 | |
| 2 | NOW Foods Phosphatidylserine 100mg NOW Foods | Best value phosphatidylserine | Phosphatidylserine (soy-free) 100mg phosphatidylserine per capsule | Veg Capsule GMP Certified, Third-Party Tested | $0.20 | 8.6/10 | |
| 3 | Doctor's Best Phosphatidylserine with SerinAid Doctor's Best | Best phosphatidylserine with the most clinically studied branded ingredient | Phosphatidylserine (SerinAid) 100mg phosphatidylserine per softgel | Softgel Third-Party Tested | $0.28 | 8.8/10 |
Detailed Reviews
Top Pick
1
Jarrow Formulas PS 100
Jarrow Formulas
9.1/10
$0.25/serving
Ingredient: Phosphatidylserine (Cogni-PS, soy-free)
Dose: 100mg phosphatidylserine per softgel
Form: Softgel
Testing: Third-Party Tested
100mg phosphatidylserine per softgelClinical range: 100-300mg daily
Clinical dose
Why we recommend it: Uses Cogni-PS — a soy-free, sunflower-derived branded phosphatidylserine with guaranteed potency. Softgel format enhances absorption of this fat-soluble phospholipid. Exact 100mg clinical dose per softgel allows flexible 1-3x daily dosing. Jarrow Formulas is a leader in phospholipid supplements.
Ideal for: Overall best phosphatidylserine for cognitive support
Not ideal for: Those seeking the cheapest per-capsule price.
Pros
- Cogni-PS branded ingredient (soy-free)
- Softgel for fat-soluble absorption
- Exact 100mg clinical dose
- Trusted Jarrow Formulas brand
Cons
- Premium price vs generic PS
- Three softgels daily for 300mg dose
- Sunflower-derived (fine for most, but noted)
2
NOW Foods Phosphatidylserine 100mg
NOW Foods
8.6/10
$0.20/serving
Ingredient: Phosphatidylserine (soy-free)
Dose: 100mg phosphatidylserine per capsule
Form: Veg Capsule
Testing: GMP Certified, Third-Party Tested
100mg phosphatidylserine per capsuleClinical range: 100-300mg daily
Clinical dose
Why we recommend it: Delivers the clinical 100mg dose at the lowest price per serving in the category. Soy-free formulation. GMP-certified manufacturing and third-party tested. NOW Foods consistently delivers quality at the best value. Veg capsule suits vegetarians.
Ideal for: Best value phosphatidylserine
Not ideal for: Those wanting a softgel with lipid base or branded ingredient.
Pros
- Best value at $0.20/serving
- Soy-free formula
- GMP certified
- Full 100mg clinical dose
Cons
- Veg capsule (no lipid base)
- No branded ingredient
- Take with food for absorption
3
Doctor's Best Phosphatidylserine with SerinAid
Doctor's Best
8.8/10
$0.28/serving
Ingredient: Phosphatidylserine (SerinAid)
Dose: 100mg phosphatidylserine per softgel
Form: Softgel
Testing: Third-Party Tested
100mg phosphatidylserine per softgelClinical range: 100-300mg daily
Clinical dose
Why we recommend it: Uses SerinAid — the most clinically studied branded phosphatidylserine ingredient, used in many of the landmark PS cognition studies. Soy-derived SerinAid has the longest track record of safety and efficacy data. Softgel format with lipid base for optimal absorption.
Ideal for: Best phosphatidylserine with the most clinically studied branded ingredient
Not ideal for: Those with soy allergies (SerinAid is soy-derived) or seeking the lowest price.
Pros
- SerinAid (most clinically studied PS)
- Softgel with lipid base
- Longest safety/efficacy track record
- Full 100mg clinical dose
Cons
- Soy-derived (allergen concern)
- Premium price ($0.28/serving)
- Soy-based in a sunflower-trending market
How to Choose
Phosphatidylserine (PS) is a phospholipid concentrated in brain cell membranes. The clinical dose for cognitive support is 100-300mg daily, with most studies using 300mg (100mg three times daily). Choose products delivering exactly 100mg per capsule for easy dose matching. Sunflower-derived PS is the modern standard (soy-free, allergen-friendly), though soy-derived PS (like SerinAid) has the longest clinical track record. PS is fat-soluble, so softgels with a lipid base absorb better than dry capsules — or take capsules with a fat-containing meal. Look for branded ingredients (Cogni-PS, SerinAid, Sharp-PS) that guarantee batch-to-batch consistency.
How We Evaluate
Every product is scored against these weighted criteria. Our ratings reflect clinical evidence and product quality, not commission rates.
Dose per Capsule
30%Clinical studies use 100-300mg daily, typically as 100mg 3x/day. Products delivering 100mg per capsule allow flexible dosing and match the clinical protocol. Lower doses require more capsules and cost more per effective dose.
Source Material
25%Sunflower-derived phosphatidylserine is allergen-friendly and avoids soy concerns. Soy-derived PS was the original source and is well-studied but may not suit those with soy allergies or sensitivities.
Branded Ingredient
25%Branded ingredients like SerinAid (from soy) and Sharp-PS (from sunflower) provide batch-to-batch consistency and traceability. They indicate the manufacturer invested in verified raw materials rather than commodity-grade phospholipids.
Third-Party Testing
20%Independent verification of phosphatidylserine content and purity. Important because phospholipid supplements can vary in composition and PS concentration.
Frequently Asked Questions
How much phosphatidylserine should I take for memory?
How much phosphatidylserine should I take for memory?
The clinical dose is 100-300mg daily, with most studies using 300mg divided as 100mg three times daily with meals. Start with 100mg daily and increase to 300mg if needed. Benefits typically appear after 6-12 weeks of consistent use. Take with fat-containing meals for better absorption.
Is soy-derived or sunflower-derived phosphatidylserine better?
Is soy-derived or sunflower-derived phosphatidylserine better?
Both sources are effective. Soy-derived PS (like SerinAid) has the longest clinical track record — most landmark cognition studies used soy PS. Sunflower-derived PS is the modern standard, avoiding soy allergen concerns. There is no evidence that one source produces superior cognitive benefits over the other.
References
- Glade MJ, Smith K (2015). Phosphatidylserine and the human brain. Nutrition. DOI PubMed
- Kato-Kataoka A, Sakai M, Ebina R, et al. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed