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Science-Verified Brand

Integrative Therapeutics

Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.

Founded 1979Green Bay, Wisconsin93 products
Third-Party TestedNo Proprietary BlendsClinical DosingPublished COAs

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.

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All 93Digestive Enzymes 6Digestive Support 4Probiotic Supplements 3Omega-3 / Fish Oil 3Bone Health 2Immune Support 2CoQ10 Supplements 2Digestive Enzyme Supplements 2Respiratory Support 2Hormone & Aging Support 2Mineral Support 2Vitamin D Supplements 2Berberine Supplements 2Iron Supplements 1Vitamin C 1Multivitamins 1Women's Hormonal Health 1Liver Detox Support 1B Vitamins 1Mood & Sleep Support 1Vitamin B12 1Detox & Hormonal Support 1Digestive Fiber & Colon Support 1Antioxidants & Heart Health 1Stress & Sleep 1Men's Health 1Liver Support 1Brain & Nerve Health 1Heart & Energy Support 1Antioxidant & Immune Support 1Heart & Cellular Energy Support 1Antioxidant & Respiratory Support 1Stress Support 1Amino Acid Supplements 1B Vitamin Supplements 1Joint Support Supplements 1Brain & Neurological Support Supplements 1Brain & Cognitive Support 1Joint & Movement Support 1Digestive & Gut Health 1Sleep & Stress Support 1Digestive Health & Probiotics 1B-Complex Supplements 1Calcium Supplements 1Quercetin Supplements 1Adaptogen Supplements 1Sleep Supplements 1Antioxidant Supplements 1Multivitamin Supplements 1Turmeric Supplements 1Nootropic Supplements 1Hormone Balance Support 1Antioxidant & Heart Health 1Digestive & Colon Support 1Minerals 1Antioxidants 1Probiotics 1Amino Acids / Gut Health 1Gut Health / Zinc 1Bone Health / Minerals 1Iron Supplement 1Seasonal Immune Support 1GI Motility Support 1Adrenal & Stress Support 1Sleep Support 1Multivitamin 1Nootropic 1Zinc 1Probiotic 1Antioxidant & Anti-Inflammatory 1Bone & Cardiovascular Health 1Cognitive Health & Brain Function 1
ZincCapsule

Integrative Therapeutics Zinc Chelate

GMP-manufactured, bottled and tested in the USA

1 capsule per serving; 100 servings per bottle per capsule · Zinc bisglycinate (chelated zinc)

Integrative Therapeutics Zinc Chelate delivers zinc bisglycinate — a chelated form of zinc recognized for superior bioavailability compared to zinc oxide or zinc sulfate. Each capsule provides foundational immune support and antioxidant protection through zinc's role in white blood cell activation and free radical neutralization. Formulated without wheat, gluten, soy, dairy, or artificial additives. Manufactured under GMP standards since 1979.

4.7 (305)
$9.25$0.09/serving
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Vitamin CCapsule

IT Vitamin C with Quercetin

GMP Certified

Vitamin C with quercetin and bioflavonoids per 2-capsule serving (180 capsules, 90 servings) per capsule · Vitamin C + Quercetin + Citrus Bioflavonoids

Clinical-grade vitamin C capsule combining ascorbic acid with quercetin and citrus bioflavonoids for immune and antioxidant support. Vegan, gluten-free.

4.7 (291)
$42.50$0.24/serving
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Digestive & Colon SupportCapsule

IT Fiber Formula Capsules (120ct / 24srv)

GMP Certified

5 capsules per serving; 24 servings per 120-count bottle per capsule · Dietary fiber blend (True Dispersion Technology)

120 capsules using True Dispersion Technology to deliver dietary fiber for colon function and digestive health. 270 reviews at 4.5 stars. Dairy-free and vegan.

4.5 (270)
$14.75$0.12/serving
Digestive Fiber & Colon SupportCapsule

IT Blue Heron Colon Support

GMP Certified

6 capsules per serving (120 capsules, 20 servings) per capsule · Psyllium + Flax + Rice Bran + Triphala + Probiotic blend

Gentle colon support blend with psyllium, flax, rice bran, Triphala, and probiotics for intestinal and gastrointestinal health. Dairy-free. 120 capsules (20 servings).

4.5 (259)
$28.25$0.24/serving
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Digestive EnzymesCapsule

IT Similase Sensitive Stomach (180ct / 90 Servings)

GMP Certified

2 capsules per serving; 90 servings per 180-count bottle per capsule · Microbial digestive enzymes + marshmallow, slippery elm, licorice root, gamma-oryzanol

180-capsule digestive enzyme formula with marshmallow, slippery elm, licorice root, gamma-oryzanol, and microbial enzymes for sensitive GI tract support.

4.6 (237)
$50.00$0.28/serving
Omega-3 / Fish OilSoftgel

IT Pure Omega HP Fish Oil Softgels

Third-party tested for purity and potency; molecular distillation; results available to consumers

375 mg EPA + 125 mg DHA + 75 mg other omega-3s per softgel (575 mg total omega-3 per serving) per softgel · EPA (375 mg) + DHA (125 mg) per softgel

High-purity omega-3 softgels delivering 375 mg EPA + 125 mg DHA per capsule. Rosemary preservation, molecular distillation, third-party tested. 120-count bottle.

4.6 (233)
$48.25$0.40/serving
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Joint & Movement SupportTablet

Integrative Therapeutics Curcumax Pro

Third-Party Tested

2 tablets per serving, 30 servings per tablet · Meriva Curcumin Phytosome

Clinically validated Meriva curcumin paired with ApresFlex boswellia and bioavailable quercetin for daily movement and discomfort support.

4.6 (218)
$49.25$0.82/serving
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CoQ10 SupplementsSoftgel

Integrative Therapeutics UBQH Ubiquinol CoQ10 100mg

GMP Certified

1 softgel per serving, 100 mg ubiquinol (60 softgels, 60 servings) per softgel · Ubiquinol (Reduced CoQ10) 100 mg

Clinical-grade 100 mg ubiquinol (reduced, active CoQ10) softgel formulated for adults requiring higher bioavailability CoQ10 — particularly older individuals and statin users for whom standard CoQ10 conversion may be impaired. Free from salt, wheat, soy, and dairy.

4.5 (217)
$68.00$1.13/serving
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Detox & Hormonal SupportCapsule

IT Calcium D-Glucarate

GMP Certified

3 capsules per serving (90 capsules, 30 servings) per capsule · Calcium D-Glucarate

Calcium D-glucarate capsule supporting detoxification systems, estrogen metabolism, and healthy immune function. Gluten-free, dairy-free. 90 capsules (30 servings).

4.7 (215)
$44.00$0.49/serving
Brain & Nerve HealthCapsule

IT GABA 750mg Capsules (60ct)

GMP Certified

1 capsule once or twice daily; dose per capsule not disclosed in scrape data per capsule · GABA (gamma-aminobutyric acid)

Single-ingredient GABA (gamma-aminobutyric acid) capsules from Integrative Therapeutics for brain nerve function and neurochemical balance support in adults.

4.5 (211)
$21.75$0.36/serving
Sleep SupplementsCapsule

Integrative Therapeutics ProThrivers Wellness Sleep

GMP Certified

1 capsule per serving (60 capsules, 60 servings) per capsule · Melatonin + Magnesium Bisglycinate + Suntheanine L-Theanine + Magnolia Bark Extract

Clinical-grade sleep support formula designed in collaboration with naturopathic oncology expert Dr. Lise Alschuler. Combines melatonin, magnesium bisglycinate, Suntheanine L-theanine, and magnolia bark extract to support sleep onset, sleep cycle health, and restful sleep. Vegan, gluten-free, and dairy-free.

4.2 (202)
$26.75$0.45/serving
Omega-3 / Fish OilSoftgel

IT Pure Omega Ultra HP 1392 mg Softgels

Third-party tested; rosemary preservation system; GMP manufactured since 1979

1392 mg total omega-3 per softgel; specific EPA and DHA mg per softgel from label (ultra-HP concentrate formula) per softgel · Ultra-concentrated EPA + DHA per 1392 mg softgel

Ultra-high-potency omega-3 softgel delivering 1392 mg total omega-3 per capsule from sustainably sourced anchovy, jack mackerel, sardine, and mackerel. Rosemary-preserved, GMP.

4.7 (200)
$69.25$0.77/serving
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Respiratory SupportLiquid

IT V Clear EPs 7630 Drops (1 fl oz)

GMP Certified

Concentrated drops; 1 fl oz bottle, for ages 13+ per liquid · Pelargonium sidoides 1X (EPs 7630)

1 fl oz concentrated drops with Pelargonium sidoides 1X (EPs 7630) for throat, nasal, and bronchial comfort during the common cold — backed by 20+ clinical studies.

4.8 (194)
$18.75$18.75/serving
NootropicCapsule

Integrative Therapeutics Neurologix

GMP-manufactured, bottled and tested in the USA; Cognizin is a patented clinically studied ingredient

2 capsules per serving; 14 servings per 28-count bottle per capsule · Cognizin CDP-Choline + Saffron extract + Spearmint extract (Neumentix)

Neurologix is a multi-ingredient nootropic from Integrative Therapeutics combining Cognizin CDP-choline, saffron extract, and spearmint extract. It is designed to support brain energy metabolism, sustained concentration, and positive outlook without stimulants. Each serving includes clinically validated Cognizin citicoline and standardized saffron extract for mood and cognitive support. Vegan, gluten-free, and formulated under GMP standards since 1979.

4.3 (193)
$26.25$0.94/serving
Digestive EnzymesTablet

IT Bio-Zyme Pancreatic Enzyme 200ct

Third-Party Tested

2 tablets per serving (100 servings per bottle) per tablet · Undiluted Pancreatic Enzymes (Protease, Lipase, Amylase)

Undiluted pancreatic enzyme complex delivering protease, lipase, and amylase activity for comprehensive digestive and systemic enzyme support.

4.6 (188)
$43.00$0.21/serving
Mood & Sleep SupportCapsule

IT 5-HTP 100mg

GMP Certified

1 capsule per serving, 100mg 5-HTP (60 capsules, 60 servings) per capsule · 5-HTP (L-5-Hydroxytryptophan) 100mg

Clinical-grade 5-HTP 100mg from Griffonia simplicifolia seeds supporting mood outlook and restful sleep. Vegan, gluten-free, dairy-free. 60 capsules.

4.6 (183)
$24.00$0.40/serving
Sleep SupportCapsule

Integrative Therapeutics Pro-Som

GMP-manufactured; USA-bottled and tested; branded ingredients (Suntheanine, Theracurmin)

4 capsules per serving; 15 servings per 60-capsule bottle per capsule · Suntheanine L-Theanine + Magnesium + Magnolia Bark + Theracurmin (Bioavailable Curcumin)

Melatonin-free sleep support capsule combining clinically validated Suntheanine L-theanine with magnesium, magnolia bark extract, and Theracurmin (bioavailable curcumin) to support sleep quality, reduce waking after sleep onset, and promote relaxation without hormonal intervention. 60 capsules per bottle (15 servings at 4 capsules/night). Dairy-free, gluten-free, soy-free. GMP-manufactured by Integrative Therapeutics since 1979.

4.1 (160)
$43.00$0.72/serving
Hormone Balance SupportCapsule

IT Indolplex DIM 240mg Capsules (60ct / 30srv)

GMP Certified

240mg BR-DIM per serving (2 capsules); 30 servings per 60-count bottle per capsule · BR-DIM (bioavailable diindolylmethane) 240mg per serving

60 capsules of BR-DIM (bioavailable diindolylmethane) at 240mg per 2-capsule serving for estrogen metabolism and hormone balance. 153 reviews at 4.5 stars.

4.5 (153)
$50.25$0.84/serving
Digestive SupportCapsule

IT Betaine HCl with Pepsin

GMP Certified

2 capsules per serving (250 capsules, 125 servings) per capsule · Betaine HCl + Pepsin

Betaine hydrochloride plus pepsin formula supporting healthy stomach acidity, gastric function, and protein digestion. Dairy-free. 250 capsules (125 servings).

4.5 (133)
$46.00$0.18/serving
Digestive EnzymesCapsule

IT Similase Lipo Digestive Enzymes (90ct)

GMP Certified

2 capsules per serving; 45 servings per 90-count bottle per capsule · Multi-enzyme blend with enhanced lipase activity

Broad-spectrum digestive enzyme capsules with added lipase activity for fat and fat-soluble nutrient digestion. 90 capsules, 45 servings, dairy-free and vegan.

4.6 (133)
$33.50$0.37/serving
MultivitaminsCapsule

IT NutriVitamin Enzyme Complex

GMP Certified

3 capsules per serving (180 capsules, 60 servings) per capsule · Multivitamin complex + Digestive Enzymes + Vitamin C + Vitamin E + Selenium

Clinical-grade multivitamin and mineral complex with digestive enzymes, vitamin C, E, and selenium. Iron-free formula designed for ongoing nutritional maintenance.

4.5 (132)
$54.25$0.30/serving
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Omega-3 / Fish OilLiquid

IT Pure Omega Liquid Fish Oil Lemon

Third-party tested for purity and potency; molecular distillation; results available to consumers

2300 mg total omega-3 per serving: 1500 mg EPA + 500 mg DHA + 300 mg other omega-3s per liquid · EPA (1500 mg) + DHA (500 mg) per serving

Lemon-flavoured liquid fish oil delivering 2300 mg omega-3 per serving — 1500 mg EPA, 500 mg DHA, 300 mg other omegas. Molecular distillation, third-party tested.

4.7 (128)
$48.25$8.04/serving
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Liver Detox SupportCapsule

IT Detoxification Factors

GMP Certified

2 capsules per serving (60 capsules, 30 servings) per capsule · Vitamins A, C, E + 30+ ingredient detox complex

30+ ingredient clinical liver support capsule targeting phase I and II detoxification pathways with antioxidant vitamins and botanical cofactors. Dairy-free.

4.6 (114)
$36.25$0.60/serving
B VitaminsCapsule

IT Flush-Free Niacin

GMP Certified

1 capsule per serving, inositol hexaniacinate form (60 capsules, 60 servings) per capsule · Inositol hexaniacinate (flush-free niacin / vitamin B3)

Flush-free niacin as inositol hexaniacinate for cellular energy support without the skin flushing of standard niacin. Vegan, gluten-free, dairy-free. 60 capsules.

4.5 (114)
$27.00$0.45/serving

Frequently Asked Questions

Do I need a doctor to buy Integrative Therapeutics products?

Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.

Is Integrative Therapeutics a reputable brand?

Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.

How does Cortisol Manager work and is it effective?

Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.

What is SBI Protect and who should take it?

SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.

What is the difference between Integrative Therapeutics and typical store-brand supplements?

The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer