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A 2022 meta-analysis of 12 RCTs (n=1,002) found that ashwagandha supplementation significantly reduced serum cortisol...
A 2022 meta-analysis of 12 RCTs (n=1,002) found that ashwagandha supplementation significantly reduced serum cortisol levels by a weighted mean of 11.3% compared to placebo (p < 0.001). Effects were strongest with KSM-66 extract at 600mg/day for 8+ weeks.
| Study | Participants | Finding | Quality |
|---|---|---|---|
An investigation into the stress-relieving and pharmacological actions of an ashwagandha extract: A randomized, double-blind, placebo-controlled study Lopresti AL, Smith SJ, Malvi H, Kodgule R — Medicine (2019) | 60 | Ashwagandha 240mg/day reduced morning cortisol by 23% after 60 days vs placebo | High |
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract: A Double-Blind RCT Salve J, Pate S, Debnath K, Langade D — Cureus (2019) | 58 | Serum cortisol reduced significantly at both 250mg and 600mg doses after 8 weeks | High |
For adults experiencing chronic stress with elevated cortisol, 600mg of KSM-66 ashwagandha root extract daily for at least 8 weeks is a well-supported intervention. The cortisol reduction of ~11% is clinically meaningful and comparable to structured stress-management programs.
A systematic review and meta-analysis examining the effects of ashwagandha extract supplementation on serum cortisol levels and perceived stress across 12 randomized controlled trials involving 1,002 participants.
Yes. A meta-analysis of 12 RCTs found ashwagandha supplementation significantly reduced serum cortisol by an average of 11-32% compared to placebo. Both 250mg and 600mg daily doses were effective, though higher doses showed greater reductions in most trials.
Most clinical trials measured outcomes at 8 weeks, with significant cortisol reduction and stress relief seen by that point. Some studies reported noticeable improvements in perceived stress as early as 4 weeks. Consistent daily use is important for sustained effects.
Clinical trials show benefits at 250-600mg daily of a standardized root extract (like KSM-66 or Sensoril). A dose of 300mg twice daily is the most commonly studied regimen. Higher doses (600mg) showed larger cortisol reductions but also more mild side effects like drowsiness.
