Skip to main content
Supplement ScienceSupplementScience

Apigenin Dosage Guide

Evidence:Emerging
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

50mg taken 30-60 minutes before bed

Maximum dose: 100mg/day (limited human safety data at higher doses)

Dosage Recommendations

General recommendation: 50mg taken 30-60 minutes before bed

Timing: 30-60 minutes before bed for sleep. Take with a small fat-containing snack for improved absorption. • Take with food for best absorption.

Dosage by Condition

Sleep support
50mg before bedEmerging
Anxiety
50-100mg dailyEmerging
NAD+ support / longevity
50mg dailyPreliminary

Upper limit: 100mg/day (limited human safety data at higher doses)

Timing & Absorption

30-60 minutes before bed for sleep. Take with a small fat-containing snack for improved absorption.

Best taken with food for optimal absorption.

Full Apigenin Guide

References

  1. RCTAmsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology. DOI PubMed
  2. Meta-analysisZhang N, Nao J, Dong X (2025). Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements.. Current neuropharmacology. DOI PubMed
  3. Ahmadzadeh K, Roshdi Dizaji S, Ramezani F, Imani F, et al. (2024). Potential therapeutic effects of apigenin for colorectal adenocarcinoma: A systematic review and meta-analysis.. Cancer medicine. DOI PubMed
  4. Meta-analysisSingh D, Gupta M, Sarwat M, Siddique HR (2022). Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models.. Critical reviews in oncology/hematology. DOI PubMed
  5. Meta-analysisRahimi A, Alimohammadi M, Faramarzi F, Alizadeh-Navaei R, et al. (2022). The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review and meta-analysis of preclinical evidence.. Inflammopharmacology. DOI PubMed
  6. Muhammed TM, Jalil AT, Taher WM, Aminov Z, et al. (2024). The Effects of Apigenin in the Treatment of Diabetic Nephropathy: A Systematic Review of Non-clinical Studies.. Mini reviews in medicinal chemistry. DOI PubMed
  7. ReviewOlasehinde TA, Olaokun OO (2024). Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?. Inflammopharmacology. DOI PubMed
Show 2 more references
  1. Mohsenzadeh-Ledari F, Delavar MA, Moghadamnia AA, Bekhradi R, et al. (2026). Effect of Matricaria chamomilla on the Quality of Life Among Women with Menopausal Symptoms: A Triple-Blind Randomized Controlled Trial.. Journal of integrative and complementary medicine. DOI PubMed
  2. Ghaderi F, Abdollahi Mandoulakani B (2024). Investigation of the association between gene expression levels and phenolic compound content in the leaves of Sonchus arvensis plants under salinity stress.. Heliyon. DOI PubMed