General Dosage
50mg taken 30-60 minutes before bed
Maximum dose: 100mg/day (limited human safety data at higher doses)
Apigenin Dosage Guide
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Dosage Recommendations
General recommendation: 50mg taken 30-60 minutes before bed
Timing: 30-60 minutes before bed for sleep. Take with a small fat-containing snack for improved absorption. • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Sleep support | 50mg before bed | Emerging |
| Anxiety | 50-100mg daily | Emerging |
| NAD+ support / longevity | 50mg daily | Preliminary |
Upper limit: 100mg/day (limited human safety data at higher doses)
Timing & Absorption
30-60 minutes before bed for sleep. Take with a small fat-containing snack for improved absorption.
Best taken with food for optimal absorption.
References
- Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M (2000). Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacology. DOI PubMed
- Escande C, Nin V, Price NL, et al. (2013). Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. DOI PubMed
- Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology. DOI PubMed