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Apigenin Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well tolerated at typical doses
  • Sedation / drowsiness (intended effect for sleep use)
  • Potential concern for men: very high doses may inhibit aromatase and affect estrogen metabolism (theoretical at supplemental doses)
  • Mild GI discomfort (rare)
  • Allergic reactions in chamomile/ragweed-sensitive individuals (rare)

Drug & Supplement Interactions

  • Sedative medications — additive effects via GABA-A pathway
  • CYP1A2 and CYP2C9 substrates — apigenin may inhibit these enzymes at high concentrations
  • Hormone-sensitive conditions — theoretical aromatase inhibition at very high doses
  • Blood thinners — mild antiplatelet effects possible

Maximum Dose

Do not exceed: 100mg/day (limited human safety data at higher doses)

Full Apigenin Guide

References

  1. (). Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacology. DOI
  2. (). Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. DOI
  3. (). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology. DOI