Evidence-Based Benefits
- Bone density preservation — the WHI trial (n=36,282) found calcium + vitamin D supplementation reduced hip fracture risk by 29% in adherent women over 60
- Fracture prevention — a 2015 meta-analysis in BMJ (Bolland et al.) of 59 RCTs found calcium supplements modestly increase bone mineral density at all sites
- Muscle function — calcium ions trigger actin-myosin cross-bridge cycling, making it essential for every muscle contraction
- Colon health — a meta-analysis of 10 studies found calcium supplementation associated with a 22% reduced risk of colorectal adenomas
- Blood pressure — modest reductions in systolic blood pressure (1-2 mmHg) observed in meta-analyses of calcium supplementation trials