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Vitamin B9 (Folate) Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

400 mcg DFE daily for adults; 600-800 mcg in pregnancy; 500 mcg during lactation

Maximum dose: 1,000 mcg/day folic acid from supplements (UL); does not apply to food folate or methylfolate

Dosage Recommendations

General recommendation: 400 mcg DFE daily for adults; 600-800 mcg in pregnancy; 500 mcg during lactation

Timing: Any time of day; consistent daily use is key, especially for pregnancy prevention

Dosage by Condition

General health
400 mcg DFE dailyStrong
Pregnancy/preconception
600-800 mcg daily (start 1-3 months before conception)Strong
NTD history (recurrence prevention)
4,000 mcg daily under medical supervisionStrong
Depression augmentation
7.5-15 mg L-methylfolate daily (prescription Deplin)Moderate

Upper limit: 1,000 mcg/day folic acid from supplements (UL); does not apply to food folate or methylfolate

Timing & Absorption

Any time of day; consistent daily use is key, especially for pregnancy prevention

Can be taken with or without food.

Full Vitamin B9 (Folate) Guide

References

  1. RCTMRC Vitamin Study Research Group (1991). Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. DOI PubMed
  2. Meta-analysisHomocysteine Lowering Trialists' Collaboration (1998). Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ. DOI PubMed
  3. RCTPapakostas GI, Shelton RC, Zajecka JM, et al. (2012). L-methylfolate as adjunctive therapy for SSRI-resistant major depression. American Journal of Psychiatry. DOI PubMed