Safety Profile
Overall safety rating: Generally Safe
Lion's Mane Side Effects & Safety
SC
DJP
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Potential Side Effects
- Rare — mild gastrointestinal discomfort during initial use
- Skin itching in sensitive individuals (likely related to NGF stimulation)
- Possible allergic reaction in those with mushroom sensitivities
Drug & Supplement Interactions
- Anticoagulant medications — lion's mane may have mild antiplatelet effects
- Antidiabetic medications — may lower blood sugar levels additively
Maximum Dose
Do not exceed: 3000mg/day from supplements (higher doses not well-studied)
References
- Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. DOI PubMed
- Lai PL, Naidu M, Sabaratnam V, et al. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus. International Journal of Medicinal Mushrooms. DOI PubMed
- Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K (2019). Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedical Research. DOI PubMed