Quercetin — Frequently Asked Questions

Yes, for most people. Standard quercetin has notoriously poor absorption — only about 2% of an oral dose reaches the bloodstream. Quercetin phytosome achieves up to 20x higher plasma levels, meaning a 250mg phytosome dose delivers more active quercetin than 1000mg of standard quercetin dihydrate. Despite costing more per capsule, phytosome is actually more cost-effective per unit of absorbed quercetin.

Senolytics are compounds that selectively eliminate senescent cells — damaged cells that stop dividing but refuse to die and instead release inflammatory signals (the "senescence-associated secretory phenotype" or SASP). Quercetin combined with dasatinib is the most studied senolytic cocktail. On its own, quercetin has modest senolytic effects, primarily in specific cell types. True senolytic protocols typically use intermittent high doses rather than daily supplementation.