General Dosage
5 mg daily as Adequate Intake (AI); therapeutic doses of pantethine range from 600-900 mg daily
Maximum dose: No established upper limit; diarrhea and GI distress reported above 10 g/day
Vitamin B5 (Pantothenic Acid) Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 5 mg daily as Adequate Intake (AI); therapeutic doses of pantethine range from 600-900 mg daily
Timing: With meals; pantethine doses divided three times daily • Take with food for best absorption.
Dosage by Condition
General health
5-10 mg daily (usually obtained from diet)Strong
Cholesterol support
300 mg pantethine three times daily (900 mg total)Moderate
Acne (high dose)
2-10 g daily pantothenic acid (limited evidence)Preliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General health | 5-10 mg daily (usually obtained from diet) | Strong |
| Cholesterol support | 300 mg pantethine three times daily (900 mg total) | Moderate |
| Acne (high dose) | 2-10 g daily pantothenic acid (limited evidence) | Preliminary |
Upper limit: No established upper limit; diarrhea and GI distress reported above 10 g/day
Timing & Absorption
With meals; pantethine doses divided three times daily
Best taken with food for optimal absorption.
References
- RCTRumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M (2011). Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects. Nutrition Research. DOI PubMed
- ReviewLeung LH (1997). Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Medical Hypotheses. DOI PubMed