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Vitamin K2 (MK-7) Dosage Guide

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

100-200 mcg MK-7 daily with a fat-containing meal

Maximum dose: No established upper limit for K2; doses up to 360 mcg MK-7 daily used safely in trials; MK-4 used at 45 mg/day therapeutically in Japan

Dosage Recommendations

General recommendation: 100-200 mcg MK-7 daily with a fat-containing meal

Timing: With a fat-containing meal for optimal absorption; once daily for MK-7 • Take with food for best absorption.

Dosage by Condition

General bone health
100-200 mcg MK-7 dailyModerate
Osteoporosis prevention
180 mcg MK-7 daily (based on Knapen RCT)Moderate
Cardiovascular protection
100-200 mcg MK-7 dailyModerate
Vitamin D3 companion
100 mcg MK-7 per 1,000-2,000 IU D3Moderate

Upper limit: No established upper limit for K2; doses up to 360 mcg MK-7 daily used safely in trials; MK-4 used at 45 mg/day therapeutically in Japan

Timing & Absorption

With a fat-containing meal for optimal absorption; once daily for MK-7

Best taken with food for optimal absorption.

Full Vitamin K2 (MK-7) Guide

References

  1. (). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International. DOI
  2. (). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. Journal of Nutrition. DOI
  3. (). Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. DOI