General Dosage
500-2,000 GDU daily (200-800mg), taken between meals for systemic effects
Maximum dose: Up to 2,400 GDU/day (960mg) has been used in clinical trials without significant adverse effects
Bromelain Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 500-2,000 GDU daily (200-800mg), taken between meals for systemic effects
Timing: Take on an empty stomach (30 min before or 2 hours after meals) for systemic anti-inflammatory action
Dosage by Condition
Post-surgical swelling
1,000-2,000 GDU daily for 7-10 daysModerate
Sinusitis
500-1,000 GDU three times dailyModerate
Osteoarthritis
500-1,000 GDU dailyEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Post-surgical swelling | 1,000-2,000 GDU daily for 7-10 days | Moderate |
| Sinusitis | 500-1,000 GDU three times daily | Moderate |
| Osteoarthritis | 500-1,000 GDU daily | Emerging |
Upper limit: Up to 2,400 GDU/day (960mg) has been used in clinical trials without significant adverse effects
Timing & Absorption
Take on an empty stomach (30 min before or 2 hours after meals) for systemic anti-inflammatory action
Can be taken with or without food.
References
- ReviewBrien S, Lewith G, Walker A, et al. (2004). Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-Based Complementary and Alternative Medicine. DOI PubMed
- RCTBraun JM, Schneider B, Beuth HJ (2005). Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. PubMed
- RCTAkhtar NM, Naseer R, Farooqi AZ, et al. (2004). Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee. Clinical Rheumatology. DOI PubMed
- Günay UB, Tanin MK, Demiröz A (2026). Efficacy and Safety of Bromelain-Based Enzymatic Debridement for Chronic Wounds: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. DOI PubMed
- De Freitas LR, Udoma-Udofa OC, Reginato PH, Mitsui HC, et al. (2025). Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis.. Journal of burn care & research : official publication of the American Burn Association. DOI PubMed
- Meta-analysisLeelakanok N, Petchsomrit A, Janurai T, Saechan C, et al. (2023). Efficacy and safety of bromelain: A systematic review and meta-analysis.. Nutrition and health. DOI PubMed
- Avadanei-Luca S, Moraru DC, Bulgaru-Iliescu AI, Tatar R, et al. (2026). Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid®): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.. Medical sciences (Basel, Switzerland). DOI PubMed