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DIM (Diindolylmethane) Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

100-200mg BioResponse DIM daily (or 200-400mg crystalline DIM)

Maximum dose: 300mg BioResponse DIM/day (higher doses used in clinical oncology trials)

Dosage Recommendations

General recommendation: 100-200mg BioResponse DIM daily (or 200-400mg crystalline DIM)

Timing: Take with a fat-containing meal to improve absorption • Take with food for best absorption.

Dosage by Condition

Estrogen metabolism support
100-200mg BioResponse DIM dailyModerate
Liver detox enzyme support
100-200mg BioResponse DIM dailyModerate
Hormonal acne (estrogen-related)
100-150mg BioResponse DIM dailyEmerging
Prostate health (men)
100-200mg BioResponse DIM dailyEmerging

Upper limit: 300mg BioResponse DIM/day (higher doses used in clinical oncology trials)

Timing & Absorption

Take with a fat-containing meal to improve absorption

Best taken with food for optimal absorption.

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References

  1. Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF (2004). Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutrition and Cancer. DOI PubMed
  2. Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA (1991). Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proceedings of the National Academy of Sciences. DOI PubMed
  3. Reed GA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, Hurwitz A (2005). Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiology, Biomarkers & Prevention. DOI PubMed
  4. Le HT, Schaldach CM, Bheldanes LF, Firestone GL (2003). Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. Journal of Biological Chemistry. DOI PubMed