General Dosage
100-200mg enhanced-absorption DIM daily (e.g., BioResponse DIM or equivalent)
Maximum dose: 200mg enhanced-absorption DIM daily; higher doses may cause GI disturbance and are not well-studied
DIM (Diindolylmethane) Dosage Guide
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Dosage Recommendations
General recommendation: 100-200mg enhanced-absorption DIM daily (e.g., BioResponse DIM or equivalent)
Timing: With a meal containing some fat for optimal absorption • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Estrogen metabolism support | 100-200mg enhanced-absorption DIM daily | Moderate |
| Hormonal acne / PMS | 100-150mg enhanced-absorption DIM daily | Emerging |
| Post-menopausal estrogen balance | 108mg enhanced-absorption DIM daily | Moderate |
Upper limit: 200mg enhanced-absorption DIM daily; higher doses may cause GI disturbance and are not well-studied
Timing & Absorption
With a meal containing some fat for optimal absorption
Best taken with food for optimal absorption.
References
- Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF (2004). Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutrition and Cancer. DOI PubMed
- Thomson CA, Chow HHS, Wertheim BC, et al. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment. DOI PubMed