General Dosage
100-300mg daily, divided into 1-3 doses
Maximum dose: 600mg/day (higher doses not well-studied for long-term use)
Phosphatidylserine Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 100-300mg daily, divided into 1-3 doses
Timing: With meals for optimal absorption; can split into 2-3 doses • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Memory support | 100-300mg daily | Moderate |
| Cortisol reduction | 400-600mg daily | Moderate |
| ADHD (adjunct) | 200mg daily | Emerging |
Upper limit: 600mg/day (higher doses not well-studied for long-term use)
Timing & Absorption
With meals for optimal absorption; can split into 2-3 doses
Best taken with food for optimal absorption.
References
- Kato-Kataoka A, Sakai M, Ebina R, et al. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed
- Monteleone P, Beinat L, Tanzillo C, et al. (1992). Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. DOI PubMed
- Baumeister J, Barthel T, Geiss KR, Weiss M (2008). Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutritional Neuroscience. DOI PubMed