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Phosphatidylserine Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

100-300mg daily, taken with meals containing fat for optimal absorption

Maximum dose: 800mg/day (used in Monteleone cortisol study without adverse effects)

Dosage Recommendations

General recommendation: 100-300mg daily, taken with meals containing fat for optimal absorption

Timing: With meals containing dietary fat for best absorption. For cortisol: morning and evening doses. For sleep: evening dose. • Take with food for best absorption.

Dosage by Condition

Cortisol and stress management
200-400mg dailyModerate
Cognitive support
100-300mg dailyModerate
Exercise recovery
400-600mg daily around trainingEmerging
Sleep support (cortisol-related)
100-200mg in the eveningEmerging

Upper limit: 800mg/day (used in Monteleone cortisol study without adverse effects)

Timing & Absorption

With meals containing dietary fat for best absorption. For cortisol: morning and evening doses. For sleep: evening dose.

Best taken with food for optimal absorption.

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References

  1. RCTMonteleone P, Maj M, Beinat L, Natale M, Kemali D (1992). Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. European Journal of Clinical Pharmacology. DOI PubMed
  2. RCTBaumeister J, Barthel T, Geiss KR, Weiss M (2008). Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutritional Neuroscience. DOI PubMed
  3. RCTKato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed
  4. RCTStarks MA, Starks SL, Kingsley M, Purpura M, Jäger R (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition. DOI PubMed
  5. Meta-analysisBruton A, Nauman J, Hanes D, Gard M, et al. (2021). Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.. Journal of alternative and complementary medicine (New York, N.Y.). DOI PubMed
  6. Sciascia S, Sanna G, Murru V, Roccatello D, et al. (2014). Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review.. Thrombosis and haemostasis. DOI PubMed
  7. Duan H, Xu N, Yang T, Wang M, et al. (2025). Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial.. Journal of affective disorders. DOI PubMed
Show 5 more references
  1. Friling M, Jackson PA, Kennedy D, Dodd F, et al. (2025). The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial.. Nutrition journal. DOI PubMed
  2. Rheims S, Herbillon V, Gaillard S, Mercier C, et al. (2024). Phosphatidylserine enriched with polyunsaturated n-3 fatty acid supplementation for attention-deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo-controlled trial.. Epilepsia open. DOI PubMed
  3. Miedes D, Ortega-Luna R, Broseta S, Martínez-Hervás S, et al. (2024). Impact of a Plant Sterol Food Supplement on Eryptotic and Associated Cardiometabolic Parameters: A Randomized Placebo-Controlled Trial in Statin-Treated Patients.. Foods (Basel, Switzerland). DOI PubMed
  4. Doma KM, Lewis ED, Barracato JM, Brink LR, et al. (2023). A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive Performance of Healthy Adults with Self-Perceived Memory Problems.. Neurology and therapy. DOI PubMed
  5. Shojaei M, Sahebkar A, Khorvash F, Fallahpour S, et al. (2023). The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial.. Avicenna journal of phytomedicine. DOI PubMed