Safety Profile
Overall safety rating: Generally Safe
Phosphatidylserine Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally well-tolerated at recommended doses
- Occasional digestive discomfort (nausea, bloating) at higher doses
- Insomnia if taken late in the evening
- Rare: headache during initial use
Drug & Supplement Interactions
- Anticoagulant medications — theoretical concern of enhanced bleeding risk at high doses
- Anticholinergic drugs — PS may counteract their effects by enhancing cholinergic activity
- Cholinesterase inhibitors (donepezil) — may have additive cholinergic effects
Maximum Dose
Do not exceed: 600mg/day (higher doses not well-studied for long-term use)
References
- Kato-Kataoka A, Sakai M, Ebina R, et al. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of Clinical Biochemistry and Nutrition. DOI PubMed
- Monteleone P, Beinat L, Tanzillo C, et al. (1992). Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. DOI PubMed
- Baumeister J, Barthel T, Geiss KR, Weiss M (2008). Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutritional Neuroscience. DOI PubMed