General Dosage
10-60mg daily (60,000-120,000 SPU), taken on an empty stomach with enteric-coated formulation
Maximum dose: Up to 60mg daily has been used in clinical studies without significant adverse effects
Serrapeptase Dosage Guide
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Dosage Recommendations
General recommendation: 10-60mg daily (60,000-120,000 SPU), taken on an empty stomach with enteric-coated formulation
Timing: Take on an empty stomach (30 min before or 2 hours after meals) for systemic enzyme absorption
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Post-surgical swelling | 10-30mg (60,000 SPU) three times daily for 7 days | Emerging |
| Sinusitis | 30mg (60,000 SPU) daily | Emerging |
| General anti-inflammatory | 10-30mg daily | Preliminary |
Upper limit: Up to 60mg daily has been used in clinical studies without significant adverse effects
Timing & Absorption
Take on an empty stomach (30 min before or 2 hours after meals) for systemic enzyme absorption
Can be taken with or without food.
References
- Al-Khateeb TH, Nusair Y (2008). Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. International Journal of Oral and Maxillofacial Surgery. DOI PubMed
- Mazzone A, Catalani M, Costanzo M, et al. (1990). Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology. Journal of International Medical Research. DOI PubMed
- Bhagat S, Agarwal M, Roy V (2013). Serratiopeptidase: a systematic review of the existing evidence. International Journal of Surgery. DOI PubMed